Gene Symbol | CACYBP |
---|---|
Entrez Gene | 27101 |
Alt Symbol | GIG5, PNAS-107, S100A6BP, SIP |
Species | Human |
Gene Type | protein-coding |
Description | calcyclin binding protein |
Other Description | S100A6-binding protein|Siah-interacting protein (SIP)|calcyclin-binding protein|growth-inhibiting gene 5 protein|hCacyBP |
Swissprots | B3KSF1 Q5R370 Q9HB71 Q5R371 O60666 B2ZWH2 |
Accessions | CAC22475 EAW90982 EAW90983 Q9HB71 AF057356 AAC21458 AF275803 AAG23817 AF314752 AAG34170 AK093425 BAG52713 AK294042 BAG57394 AK313278 BAG36086 AL035305 CAA22910 AW300675 AY423723 AAS00486 BC005975 AAH05975 BC022352 AAH22352 BC067823 AAH67823 BC078151 AAH78151 BQ432793 CA951015 NM_001007214 NP_001007215 NM_014412 NP_055227 |
Function | May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1). {ECO:0000269|PubMed:16085652}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:12895292}. Cytoplasm {ECO:0000269|PubMed:12895292}. Note=Cytoplasmic at low calcium concentrations. In neuroblastoma cells, after a retinoic acid (RA) induction and calcium increase, it localizes in both the nucleus and cytoplasm. The nuclear fraction may be phosphorylated. |
Top Pathways | Wnt signaling pathway |
CACYBP (D43G11) Rabbit mAb - 8225 from Cell Signaling Technology
|
||||||||||
CACYBP Antibody - 3354 from Cell Signaling Technology
|
||||||||||
CacyBP (A-10) - sc-166163 from Santa Cruz Biotechnology
|
||||||||||
CacyBP (C-15) - sc-104120 from Santa Cruz Biotechnology
|
||||||||||
CacyBP (D-8) - sc-166195 from Santa Cruz Biotechnology
|
||||||||||
CacyBP (FL-228) - sc-98356 from Santa Cruz Biotechnology
|
||||||||||
CacyBP (H-1) - sc-166455 from Santa Cruz Biotechnology
|
||||||||||
CacyBP (T-17) - sc-104122 from Santa Cruz Biotechnology
|
||||||||||
Anti-SIAH Interacting Protein antibody - ab176730 from Abcam
|
||||||||||
Anti-SIAH Interacting Protein antibody - ab88103 from Abcam
|
||||||||||
Anti-SIAH Interacting Protein antibody [2103C3a] - ab51288 from Abcam
|
||||||||||
Anti-SIAH Interacting Protein antibody [EPR12374] - ab171972 from Abcam
|
||||||||||
Anti-SIAH Interacting Protein antibody - C-terminal - ab190610 from Abcam
|
||||||||||
Anti-CACYBP Antibody - LS-C77559 from LifeSpan Bioscience
|
||||||||||
Anti-CACYBP Antibody - LS-C306700 from LifeSpan Bioscience
|
||||||||||
Anti-CACYBP Antibody - LS-C306699 from LifeSpan Bioscience
|
||||||||||
Anti-CACYBP Antibody - LS-C309683 from LifeSpan Bioscience
|
||||||||||
Anti-CACYBP Antibody (aa150-200) - LS-C289612 from LifeSpan Bioscience
|
||||||||||
Anti-CACYBP Antibody - LS-C309684 from LifeSpan Bioscience
|
||||||||||
Anti-CACYBP Antibody (aa108-157) - LS-C81623 from LifeSpan Bioscience
|
||||||||||
Anti-CACYBP Antibody (clone 2103C3a) - LS-C184432 from LifeSpan Bioscience
|
||||||||||
Anti-CACYBP Antibody (aa160-175) - LS-C312906 from LifeSpan Bioscience
|
||||||||||
Anti-CACYBP Antibody (aa200-228) - LS-C289614 from LifeSpan Bioscience
|
||||||||||
Anti-CACYBP Antibody (clone 2103C3a) - LS-C342476 from LifeSpan Bioscience
|
||||||||||
Anti-CACYBP Antibody (aa1-228) - LS-C186409 from LifeSpan Bioscience
|