| Gene Symbol | ALOXE3 |
|---|---|
| Entrez Gene | 59344 |
| Alt Symbol | ARCI3, E-LOX, eLOX-3, eLOX3 |
| Species | Human |
| Gene Type | protein-coding |
| Description | arachidonate lipoxygenase 3 |
| Other Description | e-LOX-3|epidermal LOX-3|epidermal lipoxygenase|epidermis-type lipoxygenase 3|hydroperoxide isomerase ALOXE3|hydroperoxy icosatetraenoate dehydratase |
| Swissprots | Q9HC22 Q3ZB74 B2R981 B7Z3W0 Q9BYJ1 Q9H4F2 |
| Accessions | CAC34518 EAW90093 EAW90094 Q9BYJ1 AF182218 AAG16899 AJ269499 CAC12843 AK292732 BAF85421 AK296416 BAH12346 AK299742 BAH13114 AK313677 BAG36428 BC101938 AAI01939 BC101939 AAI01940 BC103508 AAI03509 BC104724 AAI04725 DA183156 DC376381 NM_001165960 NP_001159432 NM_021628 NP_067641 |
| Function | Non-heme iron-containing lipoxygenase which is atypical in that it displays a prominent hydroperoxide isomerase activity and a reduced dioxygenase activity compared to other lipoxygenases. The hydroperoxide isomerase activity catalyzes the isomerization of hydroperoxides, derived from arachidonic and linoleic acid by ALOX12B, into hepoxilin-type epoxyalcohols. The dioxygenase activity requires a step of activation of the enzyme by molecular oxygen. In presence of oxygen, oxygenates polyunsaturated fatty acids, including arachidonic acid, to produce fatty acid hydroperoxides. In the skin, acts downstream of ALOX12B on the linoleate moiety of esterified omega-hydroxyacyl- sphingosine (EOS) ceramides to produce an epoxy-ketone derivative, a crucial step in the conjugation of omega-hydroxyceramide to membrane proteins. Therefore plays a crucial role in the synthesis of corneocytes lipid envelope and the establishment of the skin barrier to water loss. In parallel, it may have a signaling f |
| Subcellular Location | Cytoplasm {ECO:0000255|PROSITE- ProRule:PRU00726}. |
| Tissue Specificity | Predominantly expressed in skin. |