ALOXE3

Gene Symbol	ALOXE3
Entrez Gene	59344
Alt Symbol	ARCI3, E-LOX, eLOX-3, eLOX3
Species	Human
Gene Type	protein-coding
Description	arachidonate lipoxygenase 3
Other Description	e-LOX-3|epidermal LOX-3|epidermal lipoxygenase|epidermis-type lipoxygenase 3|hydroperoxide isomerase ALOXE3|hydroperoxy icosatetraenoate dehydratase
Swissprots	Q9HC22 Q3ZB74 B2R981 B7Z3W0 Q9BYJ1 Q9H4F2
Accessions	CAC34518 EAW90093 EAW90094 Q9BYJ1 AF182218 AAG16899 AJ269499 CAC12843 AK292732 BAF85421 AK296416 BAH12346 AK299742 BAH13114 AK313677 BAG36428 BC101938 AAI01939 BC101939 AAI01940 BC103508 AAI03509 BC104724 AAI04725 DA183156 DC376381 NM_001165960 NP_001159432 NM_021628 NP_067641
Function	Non-heme iron-containing lipoxygenase which is atypical in that it displays a prominent hydroperoxide isomerase activity and a reduced dioxygenase activity compared to other lipoxygenases. The hydroperoxide isomerase activity catalyzes the isomerization of hydroperoxides, derived from arachidonic and linoleic acid by ALOX12B, into hepoxilin-type epoxyalcohols. The dioxygenase activity requires a step of activation of the enzyme by molecular oxygen. In presence of oxygen, oxygenates polyunsaturated fatty acids, including arachidonic acid, to produce fatty acid hydroperoxides. In the skin, acts downstream of ALOX12B on the linoleate moiety of esterified omega-hydroxyacyl- sphingosine (EOS) ceramides to produce an epoxy-ketone derivative, a crucial step in the conjugation of omega-hydroxyceramide to membrane proteins. Therefore plays a crucial role in the synthesis of corneocytes lipid envelope and the establishment of the skin barrier to water loss. In parallel, it may have a signaling f
Subcellular Location	Cytoplasm {ECO:0000255|PROSITE- ProRule:PRU00726}.
Tissue Specificity	Predominantly expressed in skin.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

ALOXE3 protein (His-DHFR tag) - ab127445 from Abcam Category Protein Prices $364.00 Sizes 50 µg Source E. coli Species Human

Human ALOXE3 full length protein - ab132830 from Abcam Category Protein Prices $402.00 Sizes 10 µg Source Wheat germ Species Human

ALOXE3 Antibody Blocking Peptide - LS-E219 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ALOXE3 Partial Recombinant Protein - H00059344-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human ALOXE3 Protein - H00059344-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

ALOXE3-Antibody-Center-Blocking-Peptide - BP10450c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

ALOXE3 - H00059344-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

ALOXE3 - H00059344-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

ALOXE3 - H00059344-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

ALOXE3 - H00059344-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

ALOXE3 fusion protein - ag16415 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

ALOXE3 fusion protein - Ag17223 from Proteintech Group Category Protein Source E. coli -derived, PET28a Species Human

Recombinant Arachidonate Lipoxygenase 3 (ALOXE3) - RPD085Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Arachidonate Lipoxygenase 3 (ALOXE3) - RPD085Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Human Epidermis-type lipoxygenase 3(ALOXE3) - CSB-YP863156HU CSB-EP863156HU CSB-BP863156HU CSB-MP863156HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

ALOXE3 Protein - abx163160 from Abbexa Category Protein Species Human

ALOXE3 Peptide, Human - M34GP00527H from Creative Peptides Category Peptide Source Synthetic. Species Human

Epidermis-type lipoxygenase 3 (ALOXE3), Recombinant Protein - MBS1383912 from MyBioSource Category Protein Prices $1,520.00, $1,520.00, $1,745.00, $1,745.00, $2,600.00, $2,600.00, $3,045.00, $3,045.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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