SRSF2

Gene Symbol	SRSF2
Entrez Gene	6427
Alt Symbol	PR264, SC-35, SC35, SFRS2, SFRS2A, SRp30b
Species	Human
Gene Type	protein-coding
Description	serine/arginine-rich splicing factor 2
Other Description	SR splicing factor 2|splicing component, 35 kDa|splicing factor SC35|splicing factor, arginine/serine-rich 2
Swissprots	B4DN89 H0YG49 B3KWD5 Q01130
Accessions	AAA60162 CAA53383 CAH25911 EAW89439 EAW89440 EAW89441 EAW89442 EAW89443 EAW89444 EAW89445 EAW89446 EAW89447 EAW89448 Q01130 AK092489 BAC03903 AK093626 BAC04206 AK097069 BAG53419 AK098209 BAG53593 AK123712 BAG53944 AK124792 BAG54097 AK126432 BAG54327 AK223252 BAD96972 AK297813 BAG60151 BC000339 AAH00339 BC001303 AAH01303 BC063570 BC066958 AAH66958 BC070086 AAH70086 BT007250 AAP35914 DA513281 DC361254 DQ891210 ABM82136 DQ894393 ABM85319 EB388696 M90104 AAA60306 X62447 CAA44307 XR_429913 XR_429914 XR_934515 XR_934516 NM_001195427 NP_001182356 NM_003016 NP_003007 NR_036608
Function	Necessary for the splicing of pre-mRNA. It is required for formation of the earliest ATP-dependent splicing complex and interacts with spliceosomal components bound to both the 5'- and 3'-splice sites during spliceosome assembly. It also is required for ATP-dependent interactions of both U1 and U2 snRNPs with pre- mRNA. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Binds to purine-rich RNA sequences, either 5'-AGSAGAGTA-3' (S=C or G) or 5'-GTTCGAGTA-3'. Can bind to beta-globin mRNA and commit it to the splicing pathway. The phosphorylated form (by SRPK2) is required for cellular apoptosis in response to cisplatin treatment. {ECO:0000269|PubMed:19592491, ECO:0000269|PubMed:21157427}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:21157427}. Nucleus, nucleoplasm {ECO:0000269|PubMed:21157427}. Nucleus speckle {ECO:0000269|PubMed:21157427}. Note=Phosphorylation by SRPK2 provokes its redistribution from the nuclear specke to nucleoplasm.
Top Pathways	Spliceosome, Herpes simplex infection

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human SRSF2 / SC35 ELISA Kit (Sandwich ELISA) - LS-F6874 from LifeSpan Bioscience Category ELISA Kit Prices $720.00 Sizes 1 plate Sensitivity 0.054 ng/ml Range 0.156-10 ng/ml

Human SRSF2 / SC35 ELISA Kit (Sandwich ELISA) - LS-F12659 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.156 Range 0.156-10 ng/ml

Serine/Arginine Rich Splicing Factor 2 (SRSF2), Human, ELISA Kit - SEF102Hu from ARP American Research Products Category ELISA Kit Prices $720.00 Sizes 96 t Sensitivity 0.054ng/mL Range 0.156-10ng/mL

Serine/arginine-rich splicing factor 2, SRSF2, Human, ELISA Kit - E11550h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Range 0.156-10 ng/mL

Serine/Arginine Rich Splicing Factor 2 (SRSF2), ELISA Kit - MBS2024590 from MyBioSource Category ELISA Kit Prices $380.00, $565.00, $765.00, $3,130.00, $5,670.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity Typically less than 0.054ng/mL. Range 0.156-10ng/mL

ELISA Kit for Serine/Arginine Rich Splicing Factor 2 (SRSF2) - SEF102Hu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.054ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA’s were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

ELISA Kit for Serine/Arginine Rich Splicing Factor 2 (SRSF2) - SEF102Hu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.054ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA's were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

Chicken SRSF2 / SC35 ELISA Kit (Custom ELISA) - LS-F16225 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity To be determined Range 0.156-10 ng/ml

Bovine SRSF2 / SC35 ELISA Kit (Custom ELISA) - LS-F16226 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity To be determined Range 0.156-10 ng/ml

Pig SRSF2 / SC35 ELISA Kit (Custom ELISA) - LS-F16227 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity To be determined Range 0.156-10 ng/ml

Mouse SRSF2 / SC35 ELISA Kit (Custom ELISA) - LS-F16228 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 0.156-10 ng/ml

Rat SRSF2 / SC35 ELISA Kit (Custom ELISA) - LS-F16224 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 0.156-10 ng/ml

Human Serine/arginine-rich splicing factor 2 ELISA Kit - abx250584 from Abbexa Category ELISA Kit Range 0.156 ng/ml - 10 ng/ml

Human SRSF2 ELISA Kit - abx153165 from Abbexa Category ELISA Kit Sensitivity 0.054 ng/ml Range 0.156 ng/ml - 10 ng/ml

Serine/Arginine Rich Splicing Factor 2 (SRSF2), Human, ELISA Kit - DL-SRSF2-Hu from ARP American Research Products Category ELISA Kit Prices $655.00 Sizes 96 t Range 0.156-10 ng/mL

Human SRSF2 ELISA Kit - abx570831 from Abbexa Category ELISA Kit Sensitivity 0.054 ng/ml Range 0.156 ng/ml - 10 ng/ml

Human Serine/arginine-rich splicing factor 2 ELISA Kit - EKE53800 from Biomatik Category ELISA Kit Prices $685.40, $2,912.95, $5,483.20 Sizes 96 t, 5x96t, 10x96t Sensitivity The minimum detectable dose of this kit is typically less than 0.1 ng/ml Range 0.156-10 ng/mL

SRSF2 - EKH2636 from Nordic BioSite Sensitivity 0.094ng/ml Range 0.156-10ng/ml

SRSF2 ELISA Kit (Human) : 96 Wells (OKEH02172) - OKEH02172 from Aviva Systems Biology Category ELISA Kit Prices $420.00 Sizes 96 wells Sensitivity < 0.035 ng/mL Range 0.156 - 10 ng/mL

Human SRSF2 ELISA Kit - E034754 from Biobool Category ELISA Kit Sensitivity Typically less than 0.054ng/mL.

Human Serine/arginine-rich splicing factor 2 ELISA Kit - EK2849 from Signalway Antibody Category ELISA Kit Prices $599.00 Sizes 1x96t Sensitivity less than 0.1ng/ml Range 0.156-10 ng/mL

Serine/Arginine Rich Splicing Factor 2 (SRSF2), ELISA Kit - MBS452815 from MyBioSource Category ELISA Kit Prices $415.00, $550.00, $2,425.00, $4,710.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.054ng/mL Range 0.156-10ng/mL

Serine/arginine-rich splicing factor 2, ELISA Kit - MBS2882256 from MyBioSource Category ELISA Kit Prices $380.00, $500.00, $2,170.00, $3,840.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Range 0.156-10 ng/mL

Serine/arginine-rich splicing factor 2, ELISA Kit - MBS9426686 from MyBioSource Category ELISA Kit Prices $555.00 Sizes 96 tests Sensitivity Less than 0.1ng/mL Range 0.156-10 ng/mL

Serine/Arginine Rich Splicing Factor 2 (SRSF2), ELISA Kit - MBS9377874 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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