SRSF2

Gene Symbol	SRSF2
Entrez Gene	6427
Alt Symbol	PR264, SC-35, SC35, SFRS2, SFRS2A, SRp30b
Species	Human
Gene Type	protein-coding
Description	serine/arginine-rich splicing factor 2
Other Description	SR splicing factor 2|splicing component, 35 kDa|splicing factor SC35|splicing factor, arginine/serine-rich 2
Swissprots	B4DN89 H0YG49 B3KWD5 Q01130
Accessions	AAA60162 CAA53383 CAH25911 EAW89439 EAW89440 EAW89441 EAW89442 EAW89443 EAW89444 EAW89445 EAW89446 EAW89447 EAW89448 Q01130 AK092489 BAC03903 AK093626 BAC04206 AK097069 BAG53419 AK098209 BAG53593 AK123712 BAG53944 AK124792 BAG54097 AK126432 BAG54327 AK223252 BAD96972 AK297813 BAG60151 BC000339 AAH00339 BC001303 AAH01303 BC063570 BC066958 AAH66958 BC070086 AAH70086 BT007250 AAP35914 DA513281 DC361254 DQ891210 ABM82136 DQ894393 ABM85319 EB388696 M90104 AAA60306 X62447 CAA44307 XR_429913 XR_429914 XR_934515 XR_934516 NM_001195427 NP_001182356 NM_003016 NP_003007 NR_036608
Function	Necessary for the splicing of pre-mRNA. It is required for formation of the earliest ATP-dependent splicing complex and interacts with spliceosomal components bound to both the 5'- and 3'-splice sites during spliceosome assembly. It also is required for ATP-dependent interactions of both U1 and U2 snRNPs with pre- mRNA. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Binds to purine-rich RNA sequences, either 5'-AGSAGAGTA-3' (S=C or G) or 5'-GTTCGAGTA-3'. Can bind to beta-globin mRNA and commit it to the splicing pathway. The phosphorylated form (by SRPK2) is required for cellular apoptosis in response to cisplatin treatment. {ECO:0000269|PubMed:19592491, ECO:0000269|PubMed:21157427}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:21157427}. Nucleus, nucleoplasm {ECO:0000269|PubMed:21157427}. Nucleus speckle {ECO:0000269|PubMed:21157427}. Note=Phosphorylation by SRPK2 provokes its redistribution from the nuclear specke to nucleoplasm.
Top Pathways	Spliceosome, Herpes simplex infection

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human SC35 full length protein - ab152674 from Abcam Category Protein Source Wheat germ Species Human

Human SC35 full length protein - ab82083 from Abcam Category Protein Source Baculovirus Species Human

SRSF2 / SC35 Antibody Blocking Peptide - LS-E7108 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SRSF2 / SC35 Antibody Blocking Peptide - LS-E7107 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human SC35 Protein - H00006427-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

SFRS2-Antibody-Center-Blocking-Peptide - BP2800c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SFRS2-Antibody-N-term-Blocking-Peptide - BP2800a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SFRS2 Blocking Peptide - 33R-4652 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

SFRS2 - H00006427-P01-02 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Source in vitro transl. Species Human

SFRS2 fusion protein - Ag17177 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

SFRS2 fusion protein - Ag15612 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

SC35 Peptide - 350543 from ABBIOTEC Category Peptide Prices $50.00 Sizes 100 µg

Recombinant Human Splicing Factor, Arginine/Serine-rich 2 - SFRS2-339H from Creative Biomart Category Protein Source Sf9 insect cells.

Recombinant Human SRSF2 - SRSF2-31385TH from Creative Biomart Category Protein

Recombinant Human SRSF2, His-tagged - SRSF2-8495H from Creative Biomart Category Protein Source Sf21 Cells Species Human

Recombinant Serine/Arginine Rich Splicing Factor 2 (SRSF2) - RPF102Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

SRp46 (E72) Peptide - BS9165P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant Serine/Arginine Rich Splicing Factor 2 (SRSF2) - RPF102Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Human Serine/arginine-rich splicing factor 2(SRSF2) - CSB-YP021152HU CSB-EP021152HU CSB-BP021152HU CSB-MP021152HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

SFRS2 Peptide - abx165048 from Abbexa Category Peptide Species Human, Mouse, Rat

Splicing Factor, Arginine/Serine-Rich 2, Peptide - MBS658487 from MyBioSource Category Peptide Prices $290.00 Sizes 1 mg Species Human, Rodent

Splicing Factor, Arginine/Serine-Rich 2, Peptide - MBS658916 from MyBioSource Category Peptide Prices $290.00 Sizes 1 mg Species Human, Rodent

SC35 Recombinant Protein Antigen - NBP2-47290PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

SRSF2 Peptide, Human - M34GP15180H from Creative Peptides Category Peptide Source Synthetic. Species Human

SRSF2 Recombinant Protein (OPCD07196) - OPCD07196 from Aviva Systems Biology Category Protein Source E.coli Species Human

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