AKR1C2

Gene Symbol AKR1C2
Entrez Gene 1646
Alt Symbol AKR1C-pseudo, BABP, DD, DD-2, DD/BABP, DD2, DDH2, HAKRD, HBAB, MCDR2, SRXY8, TDD
Species Human
Gene Type protein-coding
Description aldo-keto reductase family 1, member C2
Other Description 3-alpha-HSD3|aldo-keto reductase family 1 member C2|chlordecone reductase homolog HAKRD|dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III|pseudo-chlordecone reductase|testicular 17,20-desmolase deficiency|trans-1,2-dihydrobenzene-1,2-diol dehydrogenase|type II dihydrodiol dehydrogenase
Swissprots Q96A71 Q14133 Q7M4N1 B4DKR9 A8K2N9 P52895 Q5SR16
Accessions AAB38486 ABD36086 BAA92891 CAD88527 P52895 AB021654 BAA36169 AB031084 BAA92884 AB209017 BAD92254 AK091194 AK290304 BAF82993 AK296419 BAG59081 AK296686 BAG59281 AK308385 BC007024 AAH07024 BC063574 AAH63574 BT006653 AAP35299 CA450425 DA451165 DA458030 DQ890680 ABM81606 DQ893862 ABM84788 M33376 S68330 AAD14013 U05598 AAA20937 XM_011519342 XP_011517644 NM_001135241 NP_001128713 NM_001354 NP_001345 NM_205845 NP_995317
Function Works in concert with the 5-alpha/5-beta-steroid reductases to convert steroid hormones into the 3-alpha/5-alpha and 3-alpha/5-beta-tetrahydrosteroids. Catalyzes the inactivation of the most potent androgen 5-alpha-dihydrotestosterone (5-alpha- DHT) to 5-alpha-androstane-3-alpha,17-beta-diol (3-alpha-diol). Has a high bile-binding ability. {ECO:0000269|PubMed:15929998, ECO:0000269|PubMed:17034817, ECO:0000269|PubMed:17442338, ECO:0000269|PubMed:8573067}.
Subcellular Location Cytoplasm {ECO:0000305}.
Tissue Specificity Expressed in fetal testes. Expressed in fetal and adult adrenal glands. {ECO:0000269|PubMed:21802064}.
Top Pathways Steroid hormone biosynthesis, Chemical carcinogenesis, Metabolism of xenobiotics by cytochrome P450

AKR1C2 Antibody - 13035 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from MCF7 and MCF 10A cell lines and human adipocytes using AKR1C2 Antibody.

DD1-4 (H-8) - sc-390419 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
DD1-4 (H-8): sc-390419. Western blot analysis of DD1-4 expression in Hep G2 (A) and A549 (B) whole cell lysates.

DD1-4 (B-12) - sc-390560 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
DD1-4 (B-12): sc-390560. Western blot analysis of DD1-4 expression in A549 whole cell lysate.

Anti-AKR1C2 antibody - ab194429 from Abcam

Prices $370.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
All lanes : Anti-AKR1C2 antibody (ab194429) at 1/500 dilutionLane 1 : AKR1C2 transfected 293T cell lysateLane 2 : Non transfected 293T cell lysateLysates/proteins at 15 µl per lane.

Anti-AKR1C2 antibody - ab199608 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-AKR1C2 antibody (ab199608) at 1/1000 dilution + A549 lysate at 35 µgSecondaryGoat anti-rabbit IgG H&L(HRP) at 1/5000 dilution

Anti-AKR1C2 antibody - ab196775 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-AKR1C2 antibody (ab196775) at 1/500 dilutionLane 1 : COLO cell extractLane 2 : COLO cell extract with synthesized peptide

Anti-BABP / AKR1C2 Antibody (Gln60) - LS-C192108 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-BABP / AKR1C2 Antibody (aa35-84) - LS-C116553 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
AKR1C2 antibody LS-C116553 Western blot of MCF7 cell lysate.

Anti-BABP / AKR1C2 Antibody (aa71-120) - LS-C116554 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
AKR1C2 antibody LS-C116554 Western blot of MCF7 cell lysate.

Anti-BABP / AKR1C2 Antibody (aa21-70) - LS-C119709 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of extracts from COLO cells, using AKR1C2 Antibody. The lane on the right is treated with the synthesized peptide.

Anti-BABP / AKR1C2 Antibody (clone 3C11) - LS-C197033 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3C11
Western Blot analysis of AKR1C2 expression in transfected 293T cell line by AKR1C2 monoclonal antibody (M03), clone 3C11.Lane 1: AKR1C2 transfected lysate(36.7 KDa).Lane 2: Non-transfected lysate.

Anti-BABP / AKR1C2 Antibody (aa200-250) - LS-C203014 from LifeSpan Bioscience

Prices $245.00
Sizes 40 µg
Host Rabbit
Clonality Polyclonal
Western blot of cell lysates using AKR1C2 Antibody, pAb, Rabbit (1 ug/ml). The signal was developed with IRDye 800 Conjugated Goat Anti-Rabbit IgG. Predicted Size: 37 KD. Observed Size: 37 KD.

Anti-BABP / AKR1C2 Antibody (clone 1G1) - LS-C133878 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1G1
Immunoperoxidase of monoclonal antibody to AKR1C2 on formalin-fixed paraffin-embedded human placenta. [antibody concentration 3 ug/ml]

Anti-BABP / AKR1C2 Antibody (aa296-323) - LS-C156214 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
AKR1C2 Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human liver tissue followed by peroxidase-conjugated secondary antibody and DAB staining.

AKR1C2 Antibody - H00001646-A01 from Novus Biologicals

Prices $269.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
Western Blot: AKR1C2 Antibody [H00001646-A01] - Analysis of AKR1C2 expression in transfected 293T cell line by AKR1C2 polyclonal antibody (A01). Lane1: AKR1C2 transfected lysate (37 KDa). Lane2: Non-transfected lysate.

AKR1C2 Antibody - NBP1-57769 from Novus Biologicals

Prices $139.00, $329.00
Sizes 20 µl, 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: AKR1C2 Antibody [NBP1-57769] - MCF-7 whole cell lysates, concentration 0.2-1 ug/ml.

AKR1C2 Antibody - H00001646-B02P from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Western Blot: AKR1C2 Antibody [H00001646-B02P] - Analysis of AKR1C2 expression in human liver.

AKR1C2 Antibody - NBP1-57770 from Novus Biologicals

Prices $139.00, $329.00
Sizes 20 µl, 100 µl
Host Rabbit
Clonality Polyclonal

AKR1C2 Antibody - NBP1-68377 from Novus Biologicals

Prices $229.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western Blot: AKR1C2 Antibody [NBP1-68377] - Analysis of extracts from COLO cells, using AKR1C2 Antibody. The lane on the right is treated with the synthesized peptide.

AKR1C2 Antibody (3C11) - H00001646-M03 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3C11

AKR1C2 Antibody - H00001646-D01 from Novus Biologicals

Host Rabbit
Clonality Polyclonal

AKR1C2 Antibody - H00001646-B03 from Novus Biologicals

Host Mouse
Clonality Polyclonal

Rabbit Anti-AKR1C2 Polyclonal Antibody - bs-6275R from Bioss

Host Rabbit
Clonality Polyclonal
Lane 1: rat brain lysates Lane 2: mouse embryo lysates probed with Anti HBAB/AKR1C2 Polyclonal Antibody, Unconjugated (bs-6275R) at 1:200 in 4˚C. Followed by conjugation to secondary antibody (bs-0295G-HRP) at 1:3000 90min in 37˚C. Predicted band 37kD. Observed band size: 37kD,47kD.

Anti-AKR1C2, (N-terminal) antibody produced in rabbit - SAB2105914 from Sigma-Aldrich

Prices $347.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-AKR1C2 (N-Terminal): <B>Cat. No. SAB2105914</B>: AKR1C2 in MCF7 cell lysates with AKR1C2 antibody at 1.0 μg/mL.

Monoclonal Anti-AKR1C2 antibody produced in mouse - SAB1401111 from Sigma-Aldrich

Prices $347.00
Sizes 200 µl
Host Mouse
Clonality Monoclonal
Clone 3C11
<B>Immunoblotting</B><BR/>Monoclonal Anti-AKR1C2, antibody produced in mouse, clone 3C11, ascites fluid: <B>Cat. No. SAB1401111</B>: Antibody concentration: 1.0 μg/mL. Specific band of ~37.11 kDa using immunogen protein lysate.
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