AKR1C2

Gene Symbol	AKR1C2
Entrez Gene	1646
Alt Symbol	AKR1C-pseudo, BABP, DD, DD-2, DD/BABP, DD2, DDH2, HAKRD, HBAB, MCDR2, SRXY8, TDD
Species	Human
Gene Type	protein-coding
Description	aldo-keto reductase family 1, member C2
Other Description	3-alpha-HSD3|aldo-keto reductase family 1 member C2|chlordecone reductase homolog HAKRD|dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III|pseudo-chlordecone reductase|testicular 17,20-desmolase deficiency|trans-1,2-dihydrobenzene-1,2-diol dehydrogenase|type II dihydrodiol dehydrogenase
Swissprots	Q96A71 Q14133 Q7M4N1 B4DKR9 A8K2N9 P52895 Q5SR16
Accessions	AAB38486 ABD36086 BAA92891 CAD88527 P52895 AB021654 BAA36169 AB031084 BAA92884 AB209017 BAD92254 AK091194 AK290304 BAF82993 AK296419 BAG59081 AK296686 BAG59281 AK308385 BC007024 AAH07024 BC063574 AAH63574 BT006653 AAP35299 CA450425 DA451165 DA458030 DQ890680 ABM81606 DQ893862 ABM84788 M33376 S68330 AAD14013 U05598 AAA20937 XM_011519342 XP_011517644 NM_001135241 NP_001128713 NM_001354 NP_001345 NM_205845 NP_995317
Function	Works in concert with the 5-alpha/5-beta-steroid reductases to convert steroid hormones into the 3-alpha/5-alpha and 3-alpha/5-beta-tetrahydrosteroids. Catalyzes the inactivation of the most potent androgen 5-alpha-dihydrotestosterone (5-alpha- DHT) to 5-alpha-androstane-3-alpha,17-beta-diol (3-alpha-diol). Has a high bile-binding ability. {ECO:0000269|PubMed:15929998, ECO:0000269|PubMed:17034817, ECO:0000269|PubMed:17442338, ECO:0000269|PubMed:8573067}.
Subcellular Location	Cytoplasm {ECO:0000305}.
Tissue Specificity	Expressed in fetal testes. Expressed in fetal and adult adrenal glands. {ECO:0000269|PubMed:21802064}.
Top Pathways	Steroid hormone biosynthesis, Chemical carcinogenesis, Metabolism of xenobiotics by cytochrome P450

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

AKR1C2-Over-expression-Lysate - LY12479a from Abgent, a WuXi AppTec company Category Cell Lysate Prices $325.00 Sizes 100 µg

AKR1C2 / DDH2 Lysate(Denatured) - H00001646-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

AKR1C2 / DDH2 Lysate (Non-Denatured) - L145T6 from Acris Antibodies Category Cell Lysate Prices $290.00 Sizes 100 µg

AKR1C2 overexpression lysate - LY400539 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

AKR1C2 overexpression lysate - LY404270 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

AKR1C2 overexpression lysate - LY427603 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

AKR1C2 293 Cell Lysate - 400540 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

AKR1C2 Overexpression Lysate (Denatured) - H00001646-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

AKR1C2 Overexpression Lysate (Native) - NBP2-04548 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

AKR1C2 Overexpression Lysate (Native) - NBL1-07435 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

DD2 (h): 293T Lysate - sc-116682 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

DD2 (h5): 293T Lysate - sc-158430 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

DD2 (h6): 293T Lysate - sc-158431 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

AKR1C2 Over-expression Lysate Product - GWB-B6CA52 from Genway Biotech Category Cell Lysate Prices $445.00 Sizes 100 µg Species Human

AKR1C2 Overexpression Lysate (Denatured) - H00001646-T02 from Novus Biologicals Category Cell Lysate Prices $299.00 Sizes 100 µl

Panoply™ Human AKR1C2 Knockdown Stable Cell Line - CSC-DC000457 from Creative biogene Category Cell Line Species Human

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