AKR1C2

Gene Symbol	AKR1C2
Entrez Gene	1646
Alt Symbol	AKR1C-pseudo, BABP, DD, DD-2, DD/BABP, DD2, DDH2, HAKRD, HBAB, MCDR2, SRXY8, TDD
Species	Human
Gene Type	protein-coding
Description	aldo-keto reductase family 1, member C2
Other Description	3-alpha-HSD3|aldo-keto reductase family 1 member C2|chlordecone reductase homolog HAKRD|dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III|pseudo-chlordecone reductase|testicular 17,20-desmolase deficiency|trans-1,2-dihydrobenzene-1,2-diol dehydrogenase|type II dihydrodiol dehydrogenase
Swissprots	Q96A71 Q14133 Q7M4N1 B4DKR9 A8K2N9 P52895 Q5SR16
Accessions	AAB38486 ABD36086 BAA92891 CAD88527 P52895 AB021654 BAA36169 AB031084 BAA92884 AB209017 BAD92254 AK091194 AK290304 BAF82993 AK296419 BAG59081 AK296686 BAG59281 AK308385 BC007024 AAH07024 BC063574 AAH63574 BT006653 AAP35299 CA450425 DA451165 DA458030 DQ890680 ABM81606 DQ893862 ABM84788 M33376 S68330 AAD14013 U05598 AAA20937 XM_011519342 XP_011517644 NM_001135241 NP_001128713 NM_001354 NP_001345 NM_205845 NP_995317
Function	Works in concert with the 5-alpha/5-beta-steroid reductases to convert steroid hormones into the 3-alpha/5-alpha and 3-alpha/5-beta-tetrahydrosteroids. Catalyzes the inactivation of the most potent androgen 5-alpha-dihydrotestosterone (5-alpha- DHT) to 5-alpha-androstane-3-alpha,17-beta-diol (3-alpha-diol). Has a high bile-binding ability. {ECO:0000269|PubMed:15929998, ECO:0000269|PubMed:17034817, ECO:0000269|PubMed:17442338, ECO:0000269|PubMed:8573067}.
Subcellular Location	Cytoplasm {ECO:0000305}.
Tissue Specificity	Expressed in fetal testes. Expressed in fetal and adult adrenal glands. {ECO:0000269|PubMed:21802064}.
Top Pathways	Steroid hormone biosynthesis, Chemical carcinogenesis, Metabolism of xenobiotics by cytochrome P450

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human AKR1C2 full length protein - ab114784 from Abcam Category Protein Prices $420.00 Sizes 10 µg Source Wheat germ Species Human

Human AKR1C2 protein fragment - ab114785 from Abcam Category Protein Prices $420.00 Sizes 10 µg Source Wheat germ Species Human

Human AKR1C2 protein fragment - ab151381 from Abcam Category Protein Prices $188.00 Sizes 10 µg Source E. coli Species Human

BABP / AKR1C2 Antibody Blocking Peptide - LS-E1520 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

BABP / AKR1C2 Antibody Blocking Peptide - LS-E19326 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

BABP / AKR1C2 Antibody Blocking Peptide - LS-E19327 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human AKR1C2 Protein - H00001646-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human AKR1C2 Protein - H00001646-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

AKR1C2-Antibody-C-term-Blocking-peptide - BP12246b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Human AKR1C2 protein - orb49188 from Biorbyt Category Protein Prices $408.00, $595.00, $1,904.00, $2,695.00 Sizes 10 μg, 50 μg, 500 μg, 1 mg Species Human

Human AKR1C2 protein - orb244010 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

Human AKR1C2 protein (His Tag) - orb138147 from Biorbyt Category Protein Prices $357.00, $570.00 Sizes 10 μg, 20 μg Source E. coli Species Human

AKR1C2 Blocking Peptide - 33R-4880 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

AKR1C2 Blocking Peptide - 33R-1968 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

D-Dimer protein - 30-AD41-A from Fitzgerald Category Protein Prices $195.00 Sizes 1 mg Species Human

AKR1C2 / DDH2 - H00001646-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

AKR1C2 / DDH2 - H00001646-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

AKR1C2 / DDH2 - H00001646-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

AKR1C2 / DDH2 - H00001646-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Aldo-Keto Reductase Family 1 Member C2, AKR1C2, Human, Recombinant - 19-C295 from ARP American Research Products Category Protein Prices $169.00 Sizes 10 µg Source E. coli Species Human

Recombinant Human AKR1C2 Enzyme - BP001704-C295 from Syd Labs Category Protein Prices $180.00, $528.00, $2,640.00 Sizes 10 µg, 50 µg, 1 mg Source E. coli-derived. Species Human

Recombinant Human AKR1C2, His tagged - AKR1C2-456H from Creative Biomart Category Protein Source E. coli Species Human

Recombinant Human AKR1C2, MYC/DDK-tagged - AKR1C2-18H from Creative Biomart Category Protein Source HEK293 cells Species Human

Recombinant Dihydrodiol Dehydrogenase 2 (DDH2) - RPQ200Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Human AKR1C2 Protein (His Tag) - 14175-H07E-10 from Sino Biological Category Protein Source E. coli Species Human

Search more