AADAT
| Gene Symbol | AADAT |
|---|---|
| Entrez Gene | 51166 |
| Alt Symbol | KAT2, KATII |
| Species | Human |
| Gene Type | protein-coding |
| Description | aminoadipate aminotransferase |
| Other Description | 2-aminoadipate aminotransferase|2-aminoadipate transaminase|KAT/AadAT|L kynurenine/alpha aminoadipate aminotransferase|alpha-aminoadipate aminotransferase|kynurenine aminotransferase II|kynurenine--oxoglutarate aminotransferase II|kynurenine--oxoglutarate transaminase 2|kynurenine--oxoglutarate transaminase II|kynurenine/alpha-aminoadipate aminotransferase, mitochondrial |
| Swissprots | Q9UL02 B3KP84 Q8N5Z0 |
| Accessions | AAY41030 EAX04770 EAX04771 EAX04772 Q8N5Z0 AF481738 AAM09683 AI190763 AK055952 BAG51596 AK314729 BAG37271 BC031068 AAH31068 HQ447955 ADQ32439 XM_006714231 XP_006714294 XM_011532020 XP_011530322 NM_001286682 NP_001273611 NM_001286683 NP_001273612 NM_016228 NP_057312 NM_182662 NP_872603 |
| Function | Transaminase with broad substrate specificity. Has transaminase activity towards aminoadipate, kynurenine, methionine and glutamate. Shows activity also towards tryptophan, aspartate and hydroxykynurenine. Accepts a variety of oxo-acids as amino- group acceptors, with a preference for 2-oxoglutarate, 2- oxocaproic acid, phenylpyruvate and alpha-oxo-gamma-methiol butyric acid. Can also use glyoxylate as amino-group acceptor (in vitro). {ECO:0000269|PubMed:18620547}. |
| Subcellular Location | Mitochondrion {ECO:0000305}. |
| Tissue Specificity | Higher expression in the liver. Also found in heart, brain, kidney, pancreas, prostate, testis and ovary. |
| Top Pathways | Lysine degradation, Tryptophan metabolism, Lysine biosynthesis, Biosynthesis of amino acids, 2-Oxocarboxylic acid metabolism |
KAT II CRISPR/Cas9 KO Plasmid (h) - sc-404191 from Santa Cruz Biotechnology
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KAT II HDR Plasmid (h) - sc-404191-HDR from Santa Cruz Biotechnology
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KAT II Double Nickase Plasmid (h) - sc-404191-NIC from Santa Cruz Biotechnology
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KAT II Double Nickase Plasmid (h2) - sc-404191-NIC-2 from Santa Cruz Biotechnology
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KAT II CRISPR Activation Plasmid (h) - sc-404191-ACT from Santa Cruz Biotechnology
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KAT II CRISPR Activation Plasmid (h2) - sc-404191-ACT-2 from Santa Cruz Biotechnology
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KAT II Lentiviral Activation Particles (h) - sc-404191-LAC from Santa Cruz Biotechnology
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KAT II Lentiviral Activation Particles (h2) - sc-404191-LAC-2 from Santa Cruz Biotechnology
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KAT II siRNA (h) - sc-77358 from Santa Cruz Biotechnology
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KAT II shRNA Plasmid (h) - sc-77358-SH from Santa Cruz Biotechnology
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KAT II shRNA (h) Lentiviral Particles - sc-77358-V from Santa Cruz Biotechnology
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KAT II siRNA (h) - sc-105588 from Santa Cruz Biotechnology
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KAT II shRNA Plasmid (h) - sc-105588-SH from Santa Cruz Biotechnology
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KAT II shRNA (h) Lentiviral Particles - sc-105588-V from Santa Cruz Biotechnology
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alpha-Aminoadipate Aminotransferase RNAi - H00051166-R01 from Novus Biologicals
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alpha-Aminoadipate Aminotransferase RNAi - H00051166-R02 from Novus Biologicals
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MISSION® esiRNA - EHU071611 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN2606 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2606 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR05806 from Sigma-Aldrich
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AADAT siRNA (Human) - CRH9576 from Cohesion Biosciences
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AADAT - MBS829649 from MyBioSource
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shRNA set against Human AADAT (NM_182662.1) - SHH228578 from Creative biogene
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shRNA set against Human AADAT(NM_016228.3) - SHG021937 from Creative biogene
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AADAT shRNA Plasmid (Human) - CHH9576 from Cohesion Biosciences
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