Gene Symbol |
CPSF2
|
Entrez Gene |
53981
|
Alt Symbol |
CPSF100
|
Species |
Human
|
Gene Type |
protein-coding
|
Description |
cleavage and polyadenylation specific factor 2, 100kDa
|
Other Description |
CPSF 100 kDa subunit|CPSF 100kDa subunit|cleavage and polyadenylation specificity factor 100 kDa subunit|cleavage and polyadenylation specificity factor subunit 2
|
Swissprots |
B3KME1 Q9H3W7 Q6NSJ1 Q9P2I0
|
Accessions |
EAW81480 EAW81481 EAW81482 EAW81483 Q9P2I0 AB037788 BAA92605 AK001627 BAG50953 AK001912 BAG50992 AK023583 BAG51207 AL442079 CAC09445 AU132572 BC060854 BC070095 AAH70095 BU071571 DB081880 XM_005267767 XP_005267824 NM_017437 NP_059133
|
Function |
Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Involved in the histone 3' end pre-mRNA processing. {ECO:0000269|PubMed:14749727, ECO:0000269|PubMed:18688255}.
|
Subcellular Location |
Nucleus {ECO:0000305}.
|
Top Pathways |
mRNA surveillance pathway
|