Gene Symbol | CPSF2 |
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Entrez Gene | 53981 |
Alt Symbol | CPSF100 |
Species | Human |
Gene Type | protein-coding |
Description | cleavage and polyadenylation specific factor 2, 100kDa |
Other Description | CPSF 100 kDa subunit|CPSF 100kDa subunit|cleavage and polyadenylation specificity factor 100 kDa subunit|cleavage and polyadenylation specificity factor subunit 2 |
Swissprots | B3KME1 Q9H3W7 Q6NSJ1 Q9P2I0 |
Accessions | EAW81480 EAW81481 EAW81482 EAW81483 Q9P2I0 AB037788 BAA92605 AK001627 BAG50953 AK001912 BAG50992 AK023583 BAG51207 AL442079 CAC09445 AU132572 BC060854 BC070095 AAH70095 BU071571 DB081880 XM_005267767 XP_005267824 NM_017437 NP_059133 |
Function | Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Involved in the histone 3' end pre-mRNA processing. {ECO:0000269|PubMed:14749727, ECO:0000269|PubMed:18688255}. |
Subcellular Location | Nucleus {ECO:0000305}. |
Top Pathways | mRNA surveillance pathway |
CPSF2 CRISPR/Cas9 KO Plasmid (h) - sc-407012 from Santa Cruz Biotechnology
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CPSF2 HDR Plasmid (h) - sc-407012-HDR from Santa Cruz Biotechnology
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CPSF2 Double Nickase Plasmid (h) - sc-407012-NIC from Santa Cruz Biotechnology
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CPSF2 Double Nickase Plasmid (h2) - sc-407012-NIC-2 from Santa Cruz Biotechnology
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CPSF2 CRISPR Activation Plasmid (h) - sc-407012-ACT from Santa Cruz Biotechnology
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CPSF2 CRISPR Activation Plasmid (h2) - sc-407012-ACT-2 from Santa Cruz Biotechnology
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CPSF2 Lentiviral Activation Particles (h) - sc-407012-LAC from Santa Cruz Biotechnology
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CPSF2 Lentiviral Activation Particles (h2) - sc-407012-LAC-2 from Santa Cruz Biotechnology
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CPSF2 siRNA (h) - sc-105242 from Santa Cruz Biotechnology
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CPSF2 shRNA Plasmid (h) - sc-105242-SH from Santa Cruz Biotechnology
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CPSF2 shRNA (h) Lentiviral Particles - sc-105242-V from Santa Cruz Biotechnology
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CPSF2 RNAi - H00053981-R01 from Novus Biologicals
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MISSION® esiRNA - EHU006021 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN6523 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6523 from Sigma-Aldrich
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CPSF2 siRNA (Human) - CRJ0007 from Cohesion Biosciences
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CPSF2 - MBS8221062 from MyBioSource
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shRNA set against Human Cpsf2 (NM_017437.2) - SHH268921 from Creative biogene
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Human CPSF2 siRNA - orb270508 from Biorbyt
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CPSF2 shRNA Plasmid (Human) - CHJ0007 from Cohesion Biosciences
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