| Gene Symbol |
CLEC2A
|
| Entrez Gene |
387836
|
| Alt Symbol |
INPE5792, KACL, PILAR, UNQ5792
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
C-type lectin domain family 2, member A
|
| Other Description |
C-type lectin domain family 2 member A|keratinocyte-associated C-type lectin|proliferation-induced lymphocyte-associated receptor
|
| Swissprots |
A9QKS2 Q6UVW9 A9QKS3 A5Y4G5
|
| Accessions |
EAW96129 EAW96130 Q6UVW9 AY359126 AAQ89483 EF127467 ABO33172 EU095393 ABW79912 EU095394 ABW79913 XM_011520654 XP_011518956 XM_011520655 XP_011518957 XM_011520656 XP_011518958 XM_011520657 XP_011518959 XR_931289 NM_001130711 NP_001124183 NM_207375 NP_997258
|
| Function |
Plays a role in modulating the extent of T-cell expansion. Enhances the expansion of TCR-stimulated T-cells by increasing their survival through enhanced expression of anti- apoptotic proteins. May modulate the capacity of T-cells to home to lymph nodes through SELL. Facilitates dedicated immune recognition of keratinocytes via interaction with its receptor KLRF2 by stimulating natural killer cell mediated cytotoxicity. {ECO:0000269|PubMed:18550855, ECO:0000269|PubMed:20194751}.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:18046548, ECO:0000269|PubMed:18550855}; Single-pass type II membrane protein {ECO:0000269|PubMed:18046548, ECO:0000269|PubMed:18550855}.
|
| Tissue Specificity |
Mainly expressed in skin. Also expressed in keratinocytes, spleen, thymus, small intestine, peripheral blood monocytes, bone marrow, ovary, testis and skin. High expression in CD8(+), B-lymphocytes and naive CD4(+) T-cells. Restricted mostly to proliferating lymphocytes. Not detected in myeloid leukocytes or natural killer (NK) cells. {ECO:0000269|PubMed:18046548, ECO:0000269|PubMed:18550855, ECO:0000269|PubMed:20194751}.
|