CLEC2A

Gene Symbol CLEC2A
Entrez Gene 387836
Alt Symbol INPE5792, KACL, PILAR, UNQ5792
Species Human
Gene Type protein-coding
Description C-type lectin domain family 2, member A
Other Description C-type lectin domain family 2 member A|keratinocyte-associated C-type lectin|proliferation-induced lymphocyte-associated receptor
Swissprots A9QKS2 Q6UVW9 A9QKS3 A5Y4G5
Accessions EAW96129 EAW96130 Q6UVW9 AY359126 AAQ89483 EF127467 ABO33172 EU095393 ABW79912 EU095394 ABW79913 XM_011520654 XP_011518956 XM_011520655 XP_011518957 XM_011520656 XP_011518958 XM_011520657 XP_011518959 XR_931289 NM_001130711 NP_001124183 NM_207375 NP_997258
Function Plays a role in modulating the extent of T-cell expansion. Enhances the expansion of TCR-stimulated T-cells by increasing their survival through enhanced expression of anti- apoptotic proteins. May modulate the capacity of T-cells to home to lymph nodes through SELL. Facilitates dedicated immune recognition of keratinocytes via interaction with its receptor KLRF2 by stimulating natural killer cell mediated cytotoxicity. {ECO:0000269|PubMed:18550855, ECO:0000269|PubMed:20194751}.
Subcellular Location Cell membrane {ECO:0000269|PubMed:18046548, ECO:0000269|PubMed:18550855}; Single-pass type II membrane protein {ECO:0000269|PubMed:18046548, ECO:0000269|PubMed:18550855}.
Tissue Specificity Mainly expressed in skin. Also expressed in keratinocytes, spleen, thymus, small intestine, peripheral blood monocytes, bone marrow, ovary, testis and skin. High expression in CD8(+), B-lymphocytes and naive CD4(+) T-cells. Restricted mostly to proliferating lymphocytes. Not detected in myeloid leukocytes or natural killer (NK) cells. {ECO:0000269|PubMed:18046548, ECO:0000269|PubMed:18550855, ECO:0000269|PubMed:20194751}.

CLEC-2A CRISPR/Cas9 KO Plasmid (h) - sc-415755 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CLEC-2A HDR Plasmid (h) - sc-415755-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CLEC-2A Double Nickase Plasmid (h) - sc-415755-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CLEC-2A Double Nickase Plasmid (h2) - sc-415755-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CLEC-2A CRISPR Activation Plasmid (h) - sc-415755-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CLEC-2A CRISPR Activation Plasmid (h2) - sc-415755-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CLEC-2A Lentiviral Activation Particles (h) - sc-415755-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CLEC-2A Lentiviral Activation Particles (h2) - sc-415755-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CLEC-2A siRNA (h) - sc-96119 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CLEC-2A shRNA Plasmid (h) - sc-96119-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CLEC-2A shRNA (h) Lentiviral Particles - sc-96119-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CompoZr® Knockout ZFN Kit - CKOZFN6208 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6208 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

CLEC2A siRNA (Human) - CRJ7761 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

CLEC2A - MBS8230559 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human CLEC2A (NM_001130711.1) - SHH265009 from Creative biogene

Category siRNA
Species Reactivities Human

Human CLEC2A siRNA - orb278262 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

CLEC2A shRNA Plasmid (Human) - CHJ7761 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human
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