CLP1

Gene Symbol	CLP1
Entrez Gene	10978
Alt Symbol	HEAB, hClp1
Species	Human
Gene Type	protein-coding
Description	cleavage and polyadenylation factor I subunit 1
Other Description	ATP/GTP-binding protein|homolog of yeast CFIA subunit Clp1p|polyadenylation factor Clp1|polynucleotide kinase Clp1|polyribonucleotide 5'-hydroxyl-kinase Clp1|pre-mRNA cleavage complex II protein Clp1
Swissprots	B4DTI8 Q92989 B2R7J6
Accessions	CAR94986 CAS91776 EAW73770 Q92989 AK300232 BAG62000 AK313007 BAG35843 BC000446 AAH00446 DA922553 U73524 AAC50780 NM_001142597 NP_001136069 NM_006831 NP_006822
Function	Polynucleotide kinase that can phosphorylate the 5'- hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double-stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Plays a key role in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex: phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; this phosphorylation event is a prerequisite for the subsequent ligation of the two exon halves and the production of a mature tRNA (PubMed:24766809, PubMed:24766810). Its role in tRNA splicing and maturation is required for cerebellar development (PubMed:24766809, PubMed:24766810). Component of the pre-mRNA cleavage complex II (CF-II), which seems to be required for mRNA 3'-end formation. Also phosphorylates the 5'-terminus of exogenously introduced shor
Subcellular Location	Nucleus {ECO:0000255|HAMAP-Rule:MF_03035, ECO:0000269|PubMed:11060040, ECO:0000269|PubMed:24766810}.
Top Pathways	mRNA surveillance pathway

• Antibodies
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

HEAB (L-20) - sc-243006 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

HEAB (T-17) - sc-243005 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-HEAB antibody - ab172683 from Abcam Prices $376.00 Sizes 50 µg Host Mouse Clonality Polyclonal

Anti-HEAB antibody - ab96309 from Abcam Prices $376.00 Sizes 50 µl Host Rabbit Clonality Polyclonal

Anti-HEAB antibody - ab130547 from Abcam Prices $376.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-HEAB antibody - ab56878 from Abcam Prices $376.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-HEAB antibody [EPR7180(2)] - ab133669 from Abcam Prices $385.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR7180(2)

Anti-HEAB antibody [EPR7181] - ab128939 from Abcam Prices $385.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR7181

Anti-CLP1 Antibody (N-Terminus, clone EPR7180(2)) - LS-C154615 from LifeSpan Bioscience Prices $485.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR7180(2)

Anti-CLP1 Antibody (aa142-371) - LS-C186405 from LifeSpan Bioscience Prices $335.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-CLP1 Antibody (aa307-336, APC) - LS-C213329 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-CLP1 Antibody (aa307-336, AP) - LS-C213330 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-CLP1 Antibody (aa307-336, Biotin) - LS-C213331 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-CLP1 Antibody (aa307-336, FITC) - LS-C213332 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-CLP1 Antibody (aa264-313) - LS-C151653 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-CLP1 Antibody (aa103-152) - LS-C151654 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-CLP1 Antibody (aa307-336, Azide-free, HRP) - LS-C213333 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-CLP1 Antibody (aa307-336, PE) - LS-C213334 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-CLP1 Antibody (aa316-426) - LS-C306996 from LifeSpan Bioscience Prices $455.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-CLP1 Antibody (aa307-336) - LS-C320453 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-CLP1 Antibody (aa307-336) - LS-C168850 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-CLP1 Antibody (Internal, clone EPR7181) - LS-C152444 from LifeSpan Bioscience Prices $485.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR7181

CL-P1/COLEC12 Antibody - NBP2-33847 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

CL-P1/COLEC12 Antibody - NBP1-98453 from Novus Biologicals Prices $139.00, $329.00 Sizes 20 µl, 100 µl Host Rabbit Clonality Polyclonal

CL-P1/COLEC12 Antibody - NBP1-98452 from Novus Biologicals Prices $139.00, $329.00 Sizes 20 µl, 100 µl Host Rabbit Clonality Polyclonal

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