Gene Symbol | CLP1 |
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Entrez Gene | 10978 |
Alt Symbol | HEAB, hClp1 |
Species | Human |
Gene Type | protein-coding |
Description | cleavage and polyadenylation factor I subunit 1 |
Other Description | ATP/GTP-binding protein|homolog of yeast CFIA subunit Clp1p|polyadenylation factor Clp1|polynucleotide kinase Clp1|polyribonucleotide 5'-hydroxyl-kinase Clp1|pre-mRNA cleavage complex II protein Clp1 |
Swissprots | B4DTI8 Q92989 B2R7J6 |
Accessions | CAR94986 CAS91776 EAW73770 Q92989 AK300232 BAG62000 AK313007 BAG35843 BC000446 AAH00446 DA922553 U73524 AAC50780 NM_001142597 NP_001136069 NM_006831 NP_006822 |
Function | Polynucleotide kinase that can phosphorylate the 5'- hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double-stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Plays a key role in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex: phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; this phosphorylation event is a prerequisite for the subsequent ligation of the two exon halves and the production of a mature tRNA (PubMed:24766809, PubMed:24766810). Its role in tRNA splicing and maturation is required for cerebellar development (PubMed:24766809, PubMed:24766810). Component of the pre-mRNA cleavage complex II (CF-II), which seems to be required for mRNA 3'-end formation. Also phosphorylates the 5'-terminus of exogenously introduced shor |
Subcellular Location | Nucleus {ECO:0000255|HAMAP-Rule:MF_03035, ECO:0000269|PubMed:11060040, ECO:0000269|PubMed:24766810}. |
Top Pathways | mRNA surveillance pathway |
Human HEAB full length protein - ab161223 from Abcam
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Human HEAB protein fragment - ab161224 from Abcam
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CLP1-Antibody-C-term-Blocking-Peptide - BP17136b from Abgent, a WuXi AppTec company
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CLP1 - H00010978-P01-10 from Acris Antibodies
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CLP1 - H00010978-P01-25 from Acris Antibodies
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CLP1 - H00010978-Q01-10 from Acris Antibodies
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CLP1 - H00010978-Q01-25 from Acris Antibodies
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CLP1 fusion protein - ag6479 from Proteintech Group
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CLP1 fusion protein - Ag6537 from Proteintech Group
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Recombinant Human Polyribonucleotide 5'-hydroxyl-kinase Clp1(CLP1) - CSB-YP842174HU CSB-EP842174HU CSB-BP842174HU CSB-MP842174HU from Cusabio
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CLP1 (transcript variant 1) - TP301772 from Acris Antibodies
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Polyribonucleotide 5'-hydroxyl-kinase Clp1 (CLP1), Recombinant Protein - MBS1340920 from MyBioSource
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