CLP1

Gene Symbol CLP1
Entrez Gene 10978
Alt Symbol HEAB, hClp1
Species Human
Gene Type protein-coding
Description cleavage and polyadenylation factor I subunit 1
Other Description ATP/GTP-binding protein|homolog of yeast CFIA subunit Clp1p|polyadenylation factor Clp1|polynucleotide kinase Clp1|polyribonucleotide 5'-hydroxyl-kinase Clp1|pre-mRNA cleavage complex II protein Clp1
Swissprots B4DTI8 Q92989 B2R7J6
Accessions CAR94986 CAS91776 EAW73770 Q92989 AK300232 BAG62000 AK313007 BAG35843 BC000446 AAH00446 DA922553 U73524 AAC50780 NM_001142597 NP_001136069 NM_006831 NP_006822
Function Polynucleotide kinase that can phosphorylate the 5'- hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double-stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Plays a key role in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex: phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; this phosphorylation event is a prerequisite for the subsequent ligation of the two exon halves and the production of a mature tRNA (PubMed:24766809, PubMed:24766810). Its role in tRNA splicing and maturation is required for cerebellar development (PubMed:24766809, PubMed:24766810). Component of the pre-mRNA cleavage complex II (CF-II), which seems to be required for mRNA 3'-end formation. Also phosphorylates the 5'-terminus of exogenously introduced shor
Subcellular Location Nucleus {ECO:0000255|HAMAP-Rule:MF_03035, ECO:0000269|PubMed:11060040, ECO:0000269|PubMed:24766810}.
Top Pathways mRNA surveillance pathway

Human HEAB full length protein - ab161223 from Abcam

Category Protein
Source Wheat germ
Species Human
ab161223 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Human HEAB protein fragment - ab161224 from Abcam

Category Protein
Source Wheat germ
Species Human
ab161224 on a 12.5% SDS-PAGE stained with Coomassie Blue.

CLP1-Antibody-C-term-Blocking-Peptide - BP17136b from Abgent, a WuXi AppTec company

Category Peptide
Prices $80.00
Sizes 100 µg

CLP1 - H00010978-P01-10 from Acris Antibodies

Category Protein
Prices $380.00
Sizes 10 µg
Species Human

CLP1 - H00010978-P01-25 from Acris Antibodies

Category Protein
Prices $500.00
Sizes 25 µg
Species Human

CLP1 - H00010978-Q01-10 from Acris Antibodies

Category Protein
Prices $380.00
Sizes 10 µg
Source in vitro transl.
Species Human

CLP1 - H00010978-Q01-25 from Acris Antibodies

Category Protein
Prices $500.00
Sizes 25 µg
Source in vitro transl.
Species Human

CLP1 fusion protein - ag6479 from Proteintech Group

Category Protein
Source E. coli-derived, PGEX-4T
Species Human

CLP1 fusion protein - Ag6537 from Proteintech Group

Category Protein
Prices $199.00
Sizes 50 μg
Source E. coli -derived, PET28a
Species Human

Recombinant Human Polyribonucleotide 5'-hydroxyl-kinase Clp1(CLP1) - CSB-YP842174HU CSB-EP842174HU CSB-BP842174HU CSB-MP842174HU from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Human

CLP1 (transcript variant 1) - TP301772 from Acris Antibodies

Category Protein
Prices $680.00
Sizes 20 µg
Source HEK293 cells
Species Human
CLP1

Polyribonucleotide 5'-hydroxyl-kinase Clp1 (CLP1), Recombinant Protein - MBS1340920 from MyBioSource

Category Protein
Prices $1,200.00, $1,200.00, $1,420.00, $1,420.00, $1,940.00, $1,940.00, $2,400.00, $2,400.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Human
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