| Gene Symbol | CLP1 |
|---|---|
| Entrez Gene | 10978 |
| Alt Symbol | HEAB, hClp1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | cleavage and polyadenylation factor I subunit 1 |
| Other Description | ATP/GTP-binding protein|homolog of yeast CFIA subunit Clp1p|polyadenylation factor Clp1|polynucleotide kinase Clp1|polyribonucleotide 5'-hydroxyl-kinase Clp1|pre-mRNA cleavage complex II protein Clp1 |
| Swissprots | B4DTI8 Q92989 B2R7J6 |
| Accessions | CAR94986 CAS91776 EAW73770 Q92989 AK300232 BAG62000 AK313007 BAG35843 BC000446 AAH00446 DA922553 U73524 AAC50780 NM_001142597 NP_001136069 NM_006831 NP_006822 |
| Function | Polynucleotide kinase that can phosphorylate the 5'- hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double-stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Plays a key role in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex: phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; this phosphorylation event is a prerequisite for the subsequent ligation of the two exon halves and the production of a mature tRNA (PubMed:24766809, PubMed:24766810). Its role in tRNA splicing and maturation is required for cerebellar development (PubMed:24766809, PubMed:24766810). Component of the pre-mRNA cleavage complex II (CF-II), which seems to be required for mRNA 3'-end formation. Also phosphorylates the 5'-terminus of exogenously introduced shor |
| Subcellular Location | Nucleus {ECO:0000255|HAMAP-Rule:MF_03035, ECO:0000269|PubMed:11060040, ECO:0000269|PubMed:24766810}. |
| Top Pathways | mRNA surveillance pathway |
HEAB CRISPR/Cas9 KO Plasmid (h) - sc-408655 from Santa Cruz Biotechnology
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HEAB HDR Plasmid (h) - sc-408655-HDR from Santa Cruz Biotechnology
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HEAB Double Nickase Plasmid (h) - sc-408655-NIC from Santa Cruz Biotechnology
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HEAB Double Nickase Plasmid (h2) - sc-408655-NIC-2 from Santa Cruz Biotechnology
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HEAB CRISPR Activation Plasmid (h) - sc-408655-ACT from Santa Cruz Biotechnology
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HEAB CRISPR Activation Plasmid (h2) - sc-408655-ACT-2 from Santa Cruz Biotechnology
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HEAB Lentiviral Activation Particles (h) - sc-408655-LAC from Santa Cruz Biotechnology
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HEAB Lentiviral Activation Particles (h2) - sc-408655-LAC-2 from Santa Cruz Biotechnology
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HEAB siRNA (h) - sc-96740 from Santa Cruz Biotechnology
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HEAB shRNA Plasmid (h) - sc-96740-SH from Santa Cruz Biotechnology
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HEAB shRNA (h) Lentiviral Particles - sc-96740-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU022721 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN6254 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6254 from Sigma-Aldrich
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CLP1 siRNA (Human) - CRH7495 from Cohesion Biosciences
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CLP1 - MBS8205787 from MyBioSource
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shRNA set against Human CLP1 (NM_006831.2) - SHH265565 from Creative biogene
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Human CLP1 siRNA - orb267997 from Biorbyt
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CLP1 shRNA Plasmid (Human) - CHH7495 from Cohesion Biosciences
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CLP1 miRNA 3'UTR clone - MiUTR3H-10210 from Creative biogene
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CLP1 miRNA 3'UTR clone - MiUTR3H-10211 from Creative biogene
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