CLP1

Gene Symbol CLP1
Entrez Gene 10978
Alt Symbol HEAB, hClp1
Species Human
Gene Type protein-coding
Description cleavage and polyadenylation factor I subunit 1
Other Description ATP/GTP-binding protein|homolog of yeast CFIA subunit Clp1p|polyadenylation factor Clp1|polynucleotide kinase Clp1|polyribonucleotide 5'-hydroxyl-kinase Clp1|pre-mRNA cleavage complex II protein Clp1
Swissprots B4DTI8 Q92989 B2R7J6
Accessions CAR94986 CAS91776 EAW73770 Q92989 AK300232 BAG62000 AK313007 BAG35843 BC000446 AAH00446 DA922553 U73524 AAC50780 NM_001142597 NP_001136069 NM_006831 NP_006822
Function Polynucleotide kinase that can phosphorylate the 5'- hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double-stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Plays a key role in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex: phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; this phosphorylation event is a prerequisite for the subsequent ligation of the two exon halves and the production of a mature tRNA (PubMed:24766809, PubMed:24766810). Its role in tRNA splicing and maturation is required for cerebellar development (PubMed:24766809, PubMed:24766810). Component of the pre-mRNA cleavage complex II (CF-II), which seems to be required for mRNA 3'-end formation. Also phosphorylates the 5'-terminus of exogenously introduced shor
Subcellular Location Nucleus {ECO:0000255|HAMAP-Rule:MF_03035, ECO:0000269|PubMed:11060040, ECO:0000269|PubMed:24766810}.
Top Pathways mRNA surveillance pathway

Human CLP1 cDNA clone(NM_001142597.1) - CDFH003881 from Creative Biomart

Species Human
Accession NM_001142597.1

Human CLP1 ORF clone(NM_006831.2) - CDCH383470 from Creative Biomart

Species Human
Accession NM_006831.2

Human CLP1 ORF Clone(NM_006831.2) - CDCL159116 from Creative Biomart

Species Human
Accession NM_006831.2

Human CLP1 ORF Clone(NM_001142597.1) - CDCR351369 from Creative Biomart

Species Human
Accession NM_001142597.1

Human CLP1 ORF Clone(NM_001142597.1) - CDCR351375 from Creative Biomart

Species Human
Accession NM_001142597.1

Human CLP1 ORF clone(NM_006831.2) - CDCH383470 from Creative biogene

Species Human

Human CLP1 ORF clone (NM_001142597.1) - CDCR048260 from Creative biogene

Species Human

Human CLP1 cDNA Clone(NM_001142597.1) - CDFH003881 from Creative biogene

Species Human
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