Gene Symbol | TNIP2 |
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Entrez Gene | 79155 |
Alt Symbol | ABIN2, FLIP1, KLIP |
Species | Human |
Gene Type | protein-coding |
Description | TNFAIP3 interacting protein 2 |
Other Description | A20-binding inhibitor of NF-kappaB activation-2|TNFAIP3-interacting protein 2|fetal liver LKB1-interacting protein |
Swissprots | D3DVQ9 Q9H682 Q7L5L2 B3KTY8 Q8NFZ5 Q9BQR6 B1AKS4 |
Accessions | CAM28233 EAW82514 EAW82515 EAW82516 Q8NFZ5 AF372839 AAM21315 AJ304866 CAC34835 AK026176 BAB15382 AK096296 BAG53250 AL137262 BC002740 AAH02740 BX386180 CB157550 DA421921 NM_001161527 NP_001154999 NM_001292016 NP_001278945 NM_024309 NP_077285 |
Function | Inhibits NF-kappa-B activation by blocking the interaction of RIPK1 with its downstream effector NEMO/IKBKG. Forms a ternary complex with NFKB1 and MAP3K8 but appears to function upstream of MAP3K8 in the TLR4 signaling pathway that regulates MAP3K8 activation. Involved in activation of the MEK/ERK signaling pathway during innate immune response; this function seems to be stimulus- and cell type specific. Required for stability of MAP3K8. Involved in regulation of apoptosis in endothelial cells; promotes TEK agonist-stimulated endothelial survival. May act as transcriptional coactivator when translocated to the nucleus. Enhances CHUK-mediated NF-kappa-B activation involving NF-kappa-B p50-p65 and p50-c-Rel complexes. {ECO:0000269|PubMed:12595760, ECO:0000269|PubMed:12753905, ECO:0000269|PubMed:12933576, ECO:0000269|PubMed:14653779, ECO:0000269|PubMed:15169888, ECO:0000269|PubMed:21784860}. |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:12595760}. Nucleus {ECO:0000305}. |
Tissue Specificity | Ubiquitously expressed in all tissues examined. {ECO:0000269|PubMed:12595760}. |
Abin-2 (H-8) - sc-271850 from Santa Cruz Biotechnology
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Abin-2 (N-16) - sc-32637 from Santa Cruz Biotechnology
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Abin-2 (K-17) - sc-32638 from Santa Cruz Biotechnology
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Abin-2 (H-300) - sc-50526 from Santa Cruz Biotechnology
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Anti-TNIP2 antibody - ab155513 from Abcam
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Anti-TNIP2 antibody - ab129801 from Abcam
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Anti-TNIP2 antibody - ab13683 from Abcam
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Anti-TNIP2 / ABIN-2 Antibody - LS-C11710 from LifeSpan Bioscience
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Anti-TNIP2 / ABIN-2 Antibody - LS-C11712 from LifeSpan Bioscience
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Anti-TNIP2 / ABIN-2 Antibody - LS-C63397 from LifeSpan Bioscience
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Anti-TNIP2 / ABIN-2 Antibody (aa164-194, AP) - LS-C241965 from LifeSpan Bioscience
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Anti-TNIP2 / ABIN-2 Antibody (aa164-194, APC) - LS-C241967 from LifeSpan Bioscience
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Anti-TNIP2 / ABIN-2 Antibody (aa164-194, Biotin) - LS-C241968 from LifeSpan Bioscience
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Anti-TNIP2 / ABIN-2 Antibody (aa164-194, FITC) - LS-C241969 from LifeSpan Bioscience
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Anti-TNIP2 / ABIN-2 Antibody (aa164-194, PE) - LS-C241970 from LifeSpan Bioscience
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Anti-TNIP2 / ABIN-2 Antibody (aa164-194, Azide-free, HRP) - LS-C247100 from LifeSpan Bioscience
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Anti-TNIP2 / ABIN-2 Antibody (aa66-115) - LS-C151865 from LifeSpan Bioscience
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Anti-TNIP2 / ABIN-2 Antibody (aa127-374, Biotin) - LS-C301054 from LifeSpan Bioscience
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Anti-TNIP2 / ABIN-2 Antibody (aa127-374, FITC) - LS-C303229 from LifeSpan Bioscience
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Anti-TNIP2 / ABIN-2 Antibody (aa164-194) - LS-C330239 from LifeSpan Bioscience
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Anti-TNIP2 / ABIN-2 Antibody (aa165-194) - LS-C160082 from LifeSpan Bioscience
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Anti-TNIP2 / ABIN-2 Antibody (aa127-374) - LS-C296854 from LifeSpan Bioscience
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Anti-TNIP2 / ABIN-2 Antibody IHC-plus⢠- LS-B2082 from LifeSpan Bioscience
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TNIP2 Antibody - NB100-56701 from Novus Biologicals
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TNIP2 Antibody - NBP1-32689 from Novus Biologicals
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