TNIP2

Gene Symbol TNIP2
Entrez Gene 79155
Alt Symbol ABIN2, FLIP1, KLIP
Species Human
Gene Type protein-coding
Description TNFAIP3 interacting protein 2
Other Description A20-binding inhibitor of NF-kappaB activation-2|TNFAIP3-interacting protein 2|fetal liver LKB1-interacting protein
Swissprots D3DVQ9 Q9H682 Q7L5L2 B3KTY8 Q8NFZ5 Q9BQR6 B1AKS4
Accessions CAM28233 EAW82514 EAW82515 EAW82516 Q8NFZ5 AF372839 AAM21315 AJ304866 CAC34835 AK026176 BAB15382 AK096296 BAG53250 AL137262 BC002740 AAH02740 BX386180 CB157550 DA421921 NM_001161527 NP_001154999 NM_001292016 NP_001278945 NM_024309 NP_077285
Function Inhibits NF-kappa-B activation by blocking the interaction of RIPK1 with its downstream effector NEMO/IKBKG. Forms a ternary complex with NFKB1 and MAP3K8 but appears to function upstream of MAP3K8 in the TLR4 signaling pathway that regulates MAP3K8 activation. Involved in activation of the MEK/ERK signaling pathway during innate immune response; this function seems to be stimulus- and cell type specific. Required for stability of MAP3K8. Involved in regulation of apoptosis in endothelial cells; promotes TEK agonist-stimulated endothelial survival. May act as transcriptional coactivator when translocated to the nucleus. Enhances CHUK-mediated NF-kappa-B activation involving NF-kappa-B p50-p65 and p50-c-Rel complexes. {ECO:0000269|PubMed:12595760, ECO:0000269|PubMed:12753905, ECO:0000269|PubMed:12933576, ECO:0000269|PubMed:14653779, ECO:0000269|PubMed:15169888, ECO:0000269|PubMed:21784860}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:12595760}. Nucleus {ECO:0000305}.
Tissue Specificity Ubiquitously expressed in all tissues examined. {ECO:0000269|PubMed:12595760}.

Abin-2 CRISPR/Cas9 KO Plasmid (h) - sc-404542 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Abin-2 HDR Plasmid (h) - sc-404542-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Abin-2 Double Nickase Plasmid (h) - sc-404542-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Abin-2 Double Nickase Plasmid (h2) - sc-404542-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Abin-2 CRISPR Activation Plasmid (h) - sc-404542-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Abin-2 CRISPR Activation Plasmid (h2) - sc-404542-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Abin-2 Lentiviral Activation Particles (h) - sc-404542-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Abin-2 Lentiviral Activation Particles (h2) - sc-404542-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Abin-2 siRNA (h) - sc-44638 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Abin-2 shRNA Plasmid (h) - sc-44638-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Abin-2 shRNA (h) Lentiviral Particles - sc-44638-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU106101 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN21773 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21773 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR04986 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr04986

TNIP2 siRNA (Human) - CRJ2334 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

TNIP2 - MBS828050 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human TNIP2 (NM_024309.3) - SHH432240 from Creative biogene

Category siRNA
Species Reactivities Human

Human TNIP2 siRNA - orb272835 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

TNIP2 shRNA Plasmid (Human) - CHJ2334 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

TNIP2 miRNA 3'UTR clone - MiUTR3H-11406 from Creative biogene

Species Reactivities Human

TNIP2 miRNA 3'UTR clone - MiUTR3H-11407 from Creative biogene

Species Reactivities Human
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