| Gene Symbol |
TNIP2
|
| Entrez Gene |
79155
|
| Alt Symbol |
ABIN2, FLIP1, KLIP
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
TNFAIP3 interacting protein 2
|
| Other Description |
A20-binding inhibitor of NF-kappaB activation-2|TNFAIP3-interacting protein 2|fetal liver LKB1-interacting protein
|
| Swissprots |
D3DVQ9 Q9H682 Q7L5L2 B3KTY8 Q8NFZ5 Q9BQR6 B1AKS4
|
| Accessions |
CAM28233 EAW82514 EAW82515 EAW82516 Q8NFZ5 AF372839 AAM21315 AJ304866 CAC34835 AK026176 BAB15382 AK096296 BAG53250 AL137262 BC002740 AAH02740 BX386180 CB157550 DA421921 NM_001161527 NP_001154999 NM_001292016 NP_001278945 NM_024309 NP_077285
|
| Function |
Inhibits NF-kappa-B activation by blocking the interaction of RIPK1 with its downstream effector NEMO/IKBKG. Forms a ternary complex with NFKB1 and MAP3K8 but appears to function upstream of MAP3K8 in the TLR4 signaling pathway that regulates MAP3K8 activation. Involved in activation of the MEK/ERK signaling pathway during innate immune response; this function seems to be stimulus- and cell type specific. Required for stability of MAP3K8. Involved in regulation of apoptosis in endothelial cells; promotes TEK agonist-stimulated endothelial survival. May act as transcriptional coactivator when translocated to the nucleus. Enhances CHUK-mediated NF-kappa-B activation involving NF-kappa-B p50-p65 and p50-c-Rel complexes. {ECO:0000269|PubMed:12595760, ECO:0000269|PubMed:12753905, ECO:0000269|PubMed:12933576, ECO:0000269|PubMed:14653779, ECO:0000269|PubMed:15169888, ECO:0000269|PubMed:21784860}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:12595760}. Nucleus {ECO:0000305}.
|
| Tissue Specificity |
Ubiquitously expressed in all tissues examined. {ECO:0000269|PubMed:12595760}.
|