TNIP2

Gene Symbol	TNIP2
Entrez Gene	79155
Alt Symbol	ABIN2, FLIP1, KLIP
Species	Human
Gene Type	protein-coding
Description	TNFAIP3 interacting protein 2
Other Description	A20-binding inhibitor of NF-kappaB activation-2|TNFAIP3-interacting protein 2|fetal liver LKB1-interacting protein
Swissprots	D3DVQ9 Q9H682 Q7L5L2 B3KTY8 Q8NFZ5 Q9BQR6 B1AKS4
Accessions	CAM28233 EAW82514 EAW82515 EAW82516 Q8NFZ5 AF372839 AAM21315 AJ304866 CAC34835 AK026176 BAB15382 AK096296 BAG53250 AL137262 BC002740 AAH02740 BX386180 CB157550 DA421921 NM_001161527 NP_001154999 NM_001292016 NP_001278945 NM_024309 NP_077285
Function	Inhibits NF-kappa-B activation by blocking the interaction of RIPK1 with its downstream effector NEMO/IKBKG. Forms a ternary complex with NFKB1 and MAP3K8 but appears to function upstream of MAP3K8 in the TLR4 signaling pathway that regulates MAP3K8 activation. Involved in activation of the MEK/ERK signaling pathway during innate immune response; this function seems to be stimulus- and cell type specific. Required for stability of MAP3K8. Involved in regulation of apoptosis in endothelial cells; promotes TEK agonist-stimulated endothelial survival. May act as transcriptional coactivator when translocated to the nucleus. Enhances CHUK-mediated NF-kappa-B activation involving NF-kappa-B p50-p65 and p50-c-Rel complexes. {ECO:0000269|PubMed:12595760, ECO:0000269|PubMed:12753905, ECO:0000269|PubMed:12933576, ECO:0000269|PubMed:14653779, ECO:0000269|PubMed:15169888, ECO:0000269|PubMed:21784860}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:12595760}. Nucleus {ECO:0000305}.
Tissue Specificity	Ubiquitously expressed in all tissues examined. {ECO:0000269|PubMed:12595760}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

TNIP2 / ABIN-2 Antibody Blocking Peptide - LS-E4359 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TNIP2 / ABIN-2 Antibody Blocking Peptide - LS-E23680 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TNIP2-Antibody-Center-Blocking-Peptide - BP16658c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Human TNIP2 Protein - abx069535 from Abbexa Category Protein Source E.coli Species Human

Tumor Necrosis Factor Alpha Induced Protein 3 Interacting Protein 2 (TNIP2), Human - 20-9125 from ARP American Research Products Category Protein Prices $495.00 Sizes 50 µg Source E.coli Species Human

TNIP2 fusion protein - Ag7722 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

TNIP2 fusion protein - Ag7731 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human TNIP2, His-tagged - TNIP2-3325H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Tumor Necrosis Factor Alpha Induced Protein 3 Interacting Protein 2 (TNIP2) - RPF805Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Tumor Necrosis Factor Alpha Induced Protein 3 Interacting Protein 2 (TNIP2) - RPF805Mu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Recombinant Tumor Necrosis Factor Alpha Induced Protein 3 Interacting Protein 2 (TNIP2) - RPF805Ra01 from Uscn Life Science Inc. Category Protein Source E.coli Species Rat

Recombinant Tumor Necrosis Factor Alpha Induced Protein 3 Interacting Protein 2 (TNIP2) - RPF805Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Human TNFAIP3-interacting protein 2(TNIP2) - CSB-YP822786HU CSB-EP822786HU CSB-BP822786HU CSB-MP822786HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

TNIP2 - TP301339 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

TNIP2 Recombinant Protein Antigen - NBP2-49389PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E. coli Species Human

TNIP2 Peptide, Human - M34GP16385H from Creative Peptides Category Peptide Source Synthetic. Species Human

TNIP2 Recombinant Protein Antigen - NBP2-48949PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E. coli Species Human

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