| Gene Symbol |
AGBL5
|
| Entrez Gene |
60509
|
| Alt Symbol |
CCP5
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ATP/GTP binding protein-like 5
|
| Other Description |
ATP/GTP-binding protein-like 5|cytosolic carboxypeptidase 5|cytosolic carboxypeptidase-like protein 5
|
| Swissprots |
Q96IK8 Q53SZ0 B7Z7I7 Q9H6V0 Q9H8P8 Q8NDL9 A2VDI7 B7WPG9 D6W548 Q53SW0
|
| Accessions |
AAX93164 AAY14655 EAX00649 EAX00650 EAX00651 EAX00652 EAX00653 Q8NDL9 AI990522 AK023398 BAB14560 AK025492 BAB15151 AK302091 BAH13623 AL833844 CAD38704 BC007415 AAH07415 BC018562 BC018584 BC062326 BC131498 AAI31499 CB155754 DA901318 XM_005264477 XP_005264534 XM_006712058 XP_006712121 XM_011533011 XP_011531313 XM_011533012 XP_011531314 XM_011533013 XP_011531315 NM_001035507 NP_001030584 NM_021831 NP_068603 NR_104246
|
| Function |
Metallocarboxypeptidase that mediates tubulin deglutamylation. Specifically catalyzes the deglutamylation of the branching point glutamate side chains generated by post- translational glutamylation in proteins such as tubulins. In contrast, it is not able to act as a long-chain deglutamylase that shortens long polyglutamate chains, a process catalyzed by AGTPBP1/CCP1, AGBL2/CCP2, AGBL3/CCP3, AGBL1/CCP4 and AGBL4/CCP6. {ECO:0000250|UniProtKB:Q09M02}.
|
| Subcellular Location |
Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q09M02}. Nucleus {ECO:0000269|PubMed:23085998}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:23085998}. Midbody {ECO:0000269|PubMed:23085998}. Note=Mainly cytoplasmic. Slight accumulation in the nucleus is observed (By similarity). Colocalizes with alpha-tubulin in the mitotic spindle and with midbody microtubules in the intercellular bridges formed during cytokinesis. {ECO:0000250|UniProtKB:Q09M02, ECO:0000269|PubMed:23085998}.
|
| Tissue Specificity |
Expressed in brain.
|