| Gene Symbol | AGBL5 |
|---|---|
| Entrez Gene | 60509 |
| Alt Symbol | CCP5 |
| Species | Human |
| Gene Type | protein-coding |
| Description | ATP/GTP binding protein-like 5 |
| Other Description | ATP/GTP-binding protein-like 5|cytosolic carboxypeptidase 5|cytosolic carboxypeptidase-like protein 5 |
| Swissprots | Q96IK8 Q53SZ0 B7Z7I7 Q9H6V0 Q9H8P8 Q8NDL9 A2VDI7 B7WPG9 D6W548 Q53SW0 |
| Accessions | AAX93164 AAY14655 EAX00649 EAX00650 EAX00651 EAX00652 EAX00653 Q8NDL9 AI990522 AK023398 BAB14560 AK025492 BAB15151 AK302091 BAH13623 AL833844 CAD38704 BC007415 AAH07415 BC018562 BC018584 BC062326 BC131498 AAI31499 CB155754 DA901318 XM_005264477 XP_005264534 XM_006712058 XP_006712121 XM_011533011 XP_011531313 XM_011533012 XP_011531314 XM_011533013 XP_011531315 NM_001035507 NP_001030584 NM_021831 NP_068603 NR_104246 |
| Function | Metallocarboxypeptidase that mediates tubulin deglutamylation. Specifically catalyzes the deglutamylation of the branching point glutamate side chains generated by post- translational glutamylation in proteins such as tubulins. In contrast, it is not able to act as a long-chain deglutamylase that shortens long polyglutamate chains, a process catalyzed by AGTPBP1/CCP1, AGBL2/CCP2, AGBL3/CCP3, AGBL1/CCP4 and AGBL4/CCP6. {ECO:0000250|UniProtKB:Q09M02}. |
| Subcellular Location | Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q09M02}. Nucleus {ECO:0000269|PubMed:23085998}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:23085998}. Midbody {ECO:0000269|PubMed:23085998}. Note=Mainly cytoplasmic. Slight accumulation in the nucleus is observed (By similarity). Colocalizes with alpha-tubulin in the mitotic spindle and with midbody microtubules in the intercellular bridges formed during cytokinesis. {ECO:0000250|UniProtKB:Q09M02, ECO:0000269|PubMed:23085998}. |
| Tissue Specificity | Expressed in brain. |
CCP5 CRISPR/Cas9 KO Plasmid (h) - sc-407558 from Santa Cruz Biotechnology
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CCP5 HDR Plasmid (h) - sc-407558-HDR from Santa Cruz Biotechnology
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CCP5 Double Nickase Plasmid (h) - sc-407558-NIC from Santa Cruz Biotechnology
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CCP5 Double Nickase Plasmid (h2) - sc-407558-NIC-2 from Santa Cruz Biotechnology
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CCP5 CRISPR Activation Plasmid (h) - sc-407558-ACT from Santa Cruz Biotechnology
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CCP5 CRISPR Activation Plasmid (h2) - sc-407558-ACT-2 from Santa Cruz Biotechnology
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CCP5 Lentiviral Activation Particles (h) - sc-407558-LAC from Santa Cruz Biotechnology
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CCP5 Lentiviral Activation Particles (h2) - sc-407558-LAC-2 from Santa Cruz Biotechnology
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CCP5 siRNA (h) - sc-94774 from Santa Cruz Biotechnology
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CCP5 shRNA Plasmid (h) - sc-94774-SH from Santa Cruz Biotechnology
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CCP5 shRNA (h) Lentiviral Particles - sc-94774-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU071511 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN2940 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2940 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR02927 from Sigma-Aldrich
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AGBL5 siRNA (Human) - CRJ1811 from Cohesion Biosciences
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AGBL5 - MBS8224137 from MyBioSource
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shRNA set against Human AGBL5 (NM_021831.5) - SHH233222 from Creative biogene
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shRNA set against Human AGBL5(NM_001035507.2) - SHG044961 from Creative biogene
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shRNA set against Human AGBL5(NM_021831.5) - SHG045215 from Creative biogene
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Human AGBL5 siRNA - orb272312 from Biorbyt
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AGBL5 shRNA Plasmid (Human) - CHJ1811 from Cohesion Biosciences
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AGBL5 miRNA 3'UTR clone - MiUTR1H-00233 from Creative biogene
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AGBL5 miRNA 3'UTR clone - MiUTR1H-00234 from Creative biogene
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