Gene Symbol | AGBL5 |
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Entrez Gene | 60509 |
Alt Symbol | CCP5 |
Species | Human |
Gene Type | protein-coding |
Description | ATP/GTP binding protein-like 5 |
Other Description | ATP/GTP-binding protein-like 5|cytosolic carboxypeptidase 5|cytosolic carboxypeptidase-like protein 5 |
Swissprots | Q96IK8 Q53SZ0 B7Z7I7 Q9H6V0 Q9H8P8 Q8NDL9 A2VDI7 B7WPG9 D6W548 Q53SW0 |
Accessions | AAX93164 AAY14655 EAX00649 EAX00650 EAX00651 EAX00652 EAX00653 Q8NDL9 AI990522 AK023398 BAB14560 AK025492 BAB15151 AK302091 BAH13623 AL833844 CAD38704 BC007415 AAH07415 BC018562 BC018584 BC062326 BC131498 AAI31499 CB155754 DA901318 XM_005264477 XP_005264534 XM_006712058 XP_006712121 XM_011533011 XP_011531313 XM_011533012 XP_011531314 XM_011533013 XP_011531315 NM_001035507 NP_001030584 NM_021831 NP_068603 NR_104246 |
Function | Metallocarboxypeptidase that mediates tubulin deglutamylation. Specifically catalyzes the deglutamylation of the branching point glutamate side chains generated by post- translational glutamylation in proteins such as tubulins. In contrast, it is not able to act as a long-chain deglutamylase that shortens long polyglutamate chains, a process catalyzed by AGTPBP1/CCP1, AGBL2/CCP2, AGBL3/CCP3, AGBL1/CCP4 and AGBL4/CCP6. {ECO:0000250|UniProtKB:Q09M02}. |
Subcellular Location | Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q09M02}. Nucleus {ECO:0000269|PubMed:23085998}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:23085998}. Midbody {ECO:0000269|PubMed:23085998}. Note=Mainly cytoplasmic. Slight accumulation in the nucleus is observed (By similarity). Colocalizes with alpha-tubulin in the mitotic spindle and with midbody microtubules in the intercellular bridges formed during cytokinesis. {ECO:0000250|UniProtKB:Q09M02, ECO:0000269|PubMed:23085998}. |
Tissue Specificity | Expressed in brain. |
Human AGBL5 protein fragment - ab127254 from Abcam
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AGBL5 Antibody Blocking Peptide - LS-E1217 from LifeSpan Bioscience
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AGBL5 Antibody Blocking Peptide - LS-E19452 from LifeSpan Bioscience
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AGBL5 Antibody Blocking Peptide - LS-E19453 from LifeSpan Bioscience
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AGBL5 Antibody Blocking Peptide - LS-E27735 from LifeSpan Bioscience
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Recombinant Human AGBL5 Protein - H00060509-P01 from Novus Biologicals
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AGBL5-Antibody-N-term-Blocking-peptide - BP11785a from Abgent, a WuXi AppTec company
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Agbl5 Immunizing peptide - orb66266 from Biorbyt
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AGBL5 Blocking Peptide - 33R-6772 from Fitzgerald
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AGBL5 Blocking Peptide - 33R-7930 from Fitzgerald
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AGBL5 / CCP5 - H00060509-P01 from Acris Antibodies
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AGBL5 fusion protein - ag7817 from Proteintech Group
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AGBL5 fusion protein - ag7889 from Proteintech Group
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Recombinant Human Cytosolic carboxypeptidase-like protein 5(AGBL5) ,partial - CSB-YP839858HU CSB-EP839858HU CSB-BP839858HU CSB-MP839858HU from Cusabio
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AGBL5 / CCP5 (transcript variant 1) - TP317452 from Acris Antibodies
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AGBL5 Recombinant Protein Antigen - NBP1-83616PEP from Novus Biologicals
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AGBL5 Peptide, Human - M34GP00370H from Creative Peptides
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Cytosolic carboxypeptidase-like protein 5 (AGBL5), partial, Recombinant Protein - MBS1296396 from MyBioSource
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