Gene Symbol |
CCL15
|
Entrez Gene |
6359
|
Alt Symbol |
HCC-2, HMRP-2B, LKN-1, LKN1, MIP-1 delta, MIP-1D, MIP-5, MRP-2B, NCC-3, NCC3, SCYA15, SCYL3, SY15
|
Species |
Human
|
Gene Type |
protein-coding
|
Description |
chemokine (C-C motif) ligand 15
|
Other Description |
C-C motif chemokine 15|chemokine CC-2|leukotactin 1|macrophage inflammatory protein 5|new CC chemokine 3|small inducible cytokine subfamily A (Cys-Cys), member 15|small-inducible cytokine A15
|
Swissprots |
Q16663 Q9UM74 B2RU34 E1P651
|
Accessions |
AAC63328 EAW80110 EAW80111 EAW80112 EAW80113 Q16663 AF031587 AAB94617 AI244164 BX098368 BX497188 U58914 AAD10847 NM_004167 NM_032964 NM_032965 NP_116741
|
Function |
Chemotactic factor that attracts T-cells and monocytes, but not neutrophils, eosinophils, or B-cells. Acts mainly via CC chemokine receptor CCR1. Also binds to CCR3. CCL15(22-92), CCL15(25-92) and CCL15(29-92) are more potent chemoattractants than the small-inducible cytokine A15. {ECO:0000269|PubMed:15905581}.
|
Subcellular Location |
Secreted.
|
Tissue Specificity |
Most abundant in heart, skeletal muscle and adrenal gland. Lower levels in placenta, liver, pancreas and bone marrow. CCL15(22-92), CCL15(25-92) and CCL15(29-92) are found in high levels in synovial fluids from rheumatoid patients. {ECO:0000269|PubMed:15905581, ECO:0000269|PubMed:9558365}.
|
Top Pathways |
Cytokine-cytokine receptor interaction, Chemokine signaling pathway
|