Gene Symbol | CCL15 |
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Entrez Gene | 6359 |
Alt Symbol | HCC-2, HMRP-2B, LKN-1, LKN1, MIP-1 delta, MIP-1D, MIP-5, MRP-2B, NCC-3, NCC3, SCYA15, SCYL3, SY15 |
Species | Human |
Gene Type | protein-coding |
Description | chemokine (C-C motif) ligand 15 |
Other Description | C-C motif chemokine 15|chemokine CC-2|leukotactin 1|macrophage inflammatory protein 5|new CC chemokine 3|small inducible cytokine subfamily A (Cys-Cys), member 15|small-inducible cytokine A15 |
Swissprots | Q16663 Q9UM74 B2RU34 E1P651 |
Accessions | AAC63328 EAW80110 EAW80111 EAW80112 EAW80113 Q16663 AF031587 AAB94617 AI244164 BX098368 BX497188 U58914 AAD10847 NM_004167 NM_032964 NM_032965 NP_116741 |
Function | Chemotactic factor that attracts T-cells and monocytes, but not neutrophils, eosinophils, or B-cells. Acts mainly via CC chemokine receptor CCR1. Also binds to CCR3. CCL15(22-92), CCL15(25-92) and CCL15(29-92) are more potent chemoattractants than the small-inducible cytokine A15. {ECO:0000269|PubMed:15905581}. |
Subcellular Location | Secreted. |
Tissue Specificity | Most abundant in heart, skeletal muscle and adrenal gland. Lower levels in placenta, liver, pancreas and bone marrow. CCL15(22-92), CCL15(25-92) and CCL15(29-92) are found in high levels in synovial fluids from rheumatoid patients. {ECO:0000269|PubMed:15905581, ECO:0000269|PubMed:9558365}. |
Top Pathways | Cytokine-cytokine receptor interaction, Chemokine signaling pathway |
MIP-5 CRISPR/Cas9 KO Plasmid (h) - sc-417784 from Santa Cruz Biotechnology
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MIP-5 HDR Plasmid (h) - sc-417784-HDR from Santa Cruz Biotechnology
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MIP-5 Double Nickase Plasmid (h) - sc-417784-NIC from Santa Cruz Biotechnology
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MIP-5 Double Nickase Plasmid (h2) - sc-417784-NIC-2 from Santa Cruz Biotechnology
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MIP-5 CRISPR Activation Plasmid (h) - sc-417784-ACT from Santa Cruz Biotechnology
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MIP-5 CRISPR Activation Plasmid (h2) - sc-417784-ACT-2 from Santa Cruz Biotechnology
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MIP-5 Lentiviral Activation Particles (h) - sc-417784-LAC from Santa Cruz Biotechnology
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MIP-5 Lentiviral Activation Particles (h2) - sc-417784-LAC-2 from Santa Cruz Biotechnology
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MIP-5 siRNA (h) - sc-45786 from Santa Cruz Biotechnology
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MIP-5 shRNA Plasmid (h) - sc-45786-SH from Santa Cruz Biotechnology
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MIP-5 shRNA (h) Lentiviral Particles - sc-45786-V from Santa Cruz Biotechnology
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CCL15/MIP-1 delta RNAi - H00006359-R01 from Novus Biologicals
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CCL15/MIP-1 delta RNAi - H00006359-R03 from Novus Biologicals
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CCL15/MIP-1 delta RNAi - H00006359-R02 from Novus Biologicals
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MISSION® esiRNA - EHU114531 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN5600 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5600 from Sigma-Aldrich
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CCL15 siRNA (Human) - CRH4292 from Cohesion Biosciences
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CCL15 - MBS8214597 from MyBioSource
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Human CCL15 siRNA - orb264794 from Biorbyt
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CCL15 shRNA Plasmid (Human) - CHH4292 from Cohesion Biosciences
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CCL15 miRNA 3'UTR clone - MiUTR3H-04092 from Creative biogene
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