CASP9

Gene Symbol CASP9
Entrez Gene 842
Alt Symbol APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56
Species Human
Gene Type protein-coding
Description caspase 9, apoptosis-related cysteine peptidase
Other Description ICE-like apoptotic protease 6|apoptotic protease MCH-6|apoptotic protease activating factor 3|caspase-9|protein phosphatase 1, regulatory subunit 56
Swissprots Q53Y70 P55211 Q9UEQ3 O95348 Q9BQ62 Q5JRU9 Q92852 B4E1A3 Q5UGI1 Q9UIJ8
Accessions AAO21133 BAA82697 EAW51730 EAW51731 P55211 AA534393 AB015653 BAA78780 AB020979 BAA87905 AB209147 BAD92384 AF093130 AAD12248 AF110376 AAD13615 AJ781267 CAH03131 AK292080 BAF84769 AK292111 BAF84800 AK303743 BAG64715 AY732490 AAV33129 BC002452 AAH02452 BC006463 AAH06463 BT006911 AAP35557 DA078665 DQ891693 ABM82619 HQ447255 ADQ31742 HY027003 U56390 AAC50640 U60521 AAC50776 XM_005246014 XP_005246071 XM_011542270 XP_011540572 XM_011542271 XP_011540573 XM_011542272 XP_011540574 XM_011542273 XP_011540575 XR_946778 NM_001229 NP_001220 NM_001278054 NP_001264983 NM_032996 NP_127463 NR_102732 NR_102733
Function Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf- 1 leads to activation of the protease which then cleaves and activates caspase-3. Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP- ribose) polymerase (PARP).
Tissue Specificity Ubiquitous, with highest expression in the heart, moderate expression in liver, skeletal muscle, and pancreas. Low levels in all other tissues. Within the heart, specifically expressed in myocytes. {ECO:0000269|PubMed:16857965}.
Top Pathways Influenza A, p53 signaling pathway, VEGF signaling pathway, PI3K-Akt signaling pathway, Small cell lung cancer

Cleaved Caspase-9 (Asp330) Antibody (Human Specific) - 9501 from Cell Signaling Technology

Prices $109.00, $287.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of HeLa cells, untreated or staurosporine-treated (1 µM), and Jurkat cells, untreated or etoposide-treated, using Cleaved Caspase-9 (Asp330) Antibody (Human Specific) (upper) or Caspase-9 Antibody #9502 (Human Specific) (lower).

Cleaved Caspase-9 (Asp330) (D2D4) Rabbit mAb - 7237 from Cell Signaling Technology

Prices $109.00, $287.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D2D4
Western blot analysis of extracts from HeLa and Jurkat cells, untreated or treated with Staurosporine #9953 (1 μM, 3 hr) or etoposide (25 μM, overnight), using Cleaved Caspase-9 (Asp330) (D2D4) Rabbit mAb (upper) or total Caspase-9 Antibody (Human Specific) #9502 (lower).

Cleaved Caspase-9 (Asp315) Antibody (Human Specific) - 9505 from Cell Signaling Technology

Prices $109.00, $287.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from Jurkat cells, untreated or cytochrome c-treated (0.25 mg/ml), and HeLa cells, untreated, staurosporine-treated (1 µM), or cytochrome c-treated (0.25 mg/ml), using Cleaved Caspase-9 (Asp315) Antibody (Human Specific) (upper) or Caspase-9 Antibody (Human Specific) #9502 (lower).

Caspase-9 (C9) Mouse mAb - 9508 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Mouse
Clonality Monoclonal
Clone C9
Western blot analysis of extracts from Jurkat cells (human), L929 cells (mouse), and C6 cells (rat), untreated or treated with staurosporine or cytochrome c as indicated, using Caspase 9 (C9) Mouse mAb.

Caspase-9 Antibody (Human Specific) - 9502 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of HeLa cells, untreated, staurosporine-treated (1 µM) or cytochrome c-treated (0.25 mg/ml), and Jurkat cells, untreated or cytochrome c-treated, using Caspase-9 Antibody (Human Specific).

Phospho-Caspase-9 (Thr125) Antibody - 2226 from Cell Signaling Technology

Host Rabbit
Clonality Polyclonal

caspase-9 (1-2) - sc-56073 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
caspase-9 (1-2): sc-56073. Western blot analysis of caspase-9 expression in CCRF-CEM (A), HeLa (B) and MOLT-4 (C) whole cell lysates.

caspase-9 (96.1.23) - sc-56076 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
caspase-9 (96.1.23): sc-56076. Western blot analysis of caspase-9 expression in HeLa (A), Jurkat (B), staurosporine-treated Jurkat (C), staurosporine-treated HeLa (D), UV-treated HeLa (E) and MOLT-4 (F) whole cell lysates.

caspase-9 (9CSP02) - sc-81589 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
caspase-9 (9CSP02): sc-81589. Western blot analysis of caspase-9 expression in HuT 78 (A) and HeLa (B) whole cell lysates.

caspase-9 (9CSP01) - sc-81663 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

caspase-9 (9CSP03) - sc-73548 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
caspase-9 (9CSP03): sc-73548. Western blot analysis of caspase-9 expression in HeLa (A), Jurkat (B), HuT 78 (C), MOLT-4 (D), UV-treated HeLa (E) and staurosporine-treated HeLa (F) whole cell lysates.

caspase-9 (LAP 96-2-22) - sc-56077 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
caspase-9 (LAP 96-2-22): sc-56077. Western blot analysis of caspase-9 expression in HeLa (A), Jurkat (B), MOLT-4 (C) and HuT 78 (D) whole cell lysates.

caspase-9 (10.1.87) - sc-81650 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

caspase-9 (3C122) - sc-70505 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
caspase-9 (3C122): sc-70505. Western blot analysis of caspase-9 expression in CCRF-CEM (A), HeLa (B) and MOLT-4 (C) whole cell lysates.

caspase-9 (4E31) - sc-70506 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
caspase-9 (4E31): sc-70506. Western blot analysis of caspase-9 expression in HeLa whole cell lysate.

caspase-9 (4i31) - sc-70507 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
caspase-9 (4i31): sc-70507. Western blot analysis of caspase-9 expression in HeLa (A) and MOLT-4 (B) whole cell lysates.

caspase-9 p10 (C-17) - sc-8297 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
caspase-9 p10 (C-17): sc-8297. Western blot analysis of caspase-9 precursor expression in Jurkat whole cell lysate.

caspase-9 p10 (F-7) - sc-17784 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
caspase-9 p10 (F-7): sc-17784. Immunoperoxidase staining of formalin fixed, paraffin-embedded human placenta tissue showing nuclear and cytoplasmic staining of throphoblastic cells. Kindly provided by The Swedish Human Protein Atlas (HPA) program.

caspase-9 p10 (H-83) - sc-7885 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
caspase-9 p10 (H-83): sc-7885. Western blot analysis of caspase-9 precursor in Jurkat (A), HUT 78 (B) and MOLT-4 (C) whole cell lysates.

caspase-9 p35 (A-9) - sc-133109 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
caspase-9 p35 (A-9): sc-133109. Western blot analysis of caspase-9 p35 expression in HeLa (A), HL-60 (B) and RAW 264.7 (C) whole cell lysates.

caspase-9 p35 (H-170) - sc-8355 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
caspase-9 p35 (H-170): sc-8355. Western blot analysis of caspase-9 precursor expression in HeLa whole cell lysate.

cleaved caspase-9 p10 (h331) - sc-22182 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
cleaved caspase-9 p10 (h331): sc-22182. Western blot analysis of cleaved caspase-9 p10 expression in MIA PaCa-2 whole cell lysate.

p-caspase-9 (Ser 196) - sc-11755 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-active Caspase 9 antibody - ab2324 from Abcam

Prices $370.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-active Caspase 9 antibody (ab2324)Lane 1 : Jurkat cell lysate, untreatedLane 2 : Jurkat cell lysate, treated with etoposide for 6 hoursObserved band size : 37 kDa (why is the actual band size different from the predicted?)

Anti-Caspase 9 antibody - ab63488 from Abcam

Prices $384.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
This image shows HuvEc cells stained with ab63488 at 1/500 dilution; with and without the immunising peptide.
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