CASP9

Gene Symbol CASP9
Entrez Gene 842
Alt Symbol APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56
Species Human
Gene Type protein-coding
Description caspase 9, apoptosis-related cysteine peptidase
Other Description ICE-like apoptotic protease 6|apoptotic protease MCH-6|apoptotic protease activating factor 3|caspase-9|protein phosphatase 1, regulatory subunit 56
Swissprots Q53Y70 P55211 Q9UEQ3 O95348 Q9BQ62 Q5JRU9 Q92852 B4E1A3 Q5UGI1 Q9UIJ8
Accessions AAO21133 BAA82697 EAW51730 EAW51731 P55211 AA534393 AB015653 BAA78780 AB020979 BAA87905 AB209147 BAD92384 AF093130 AAD12248 AF110376 AAD13615 AJ781267 CAH03131 AK292080 BAF84769 AK292111 BAF84800 AK303743 BAG64715 AY732490 AAV33129 BC002452 AAH02452 BC006463 AAH06463 BT006911 AAP35557 DA078665 DQ891693 ABM82619 HQ447255 ADQ31742 HY027003 U56390 AAC50640 U60521 AAC50776 XM_005246014 XP_005246071 XM_011542270 XP_011540572 XM_011542271 XP_011540573 XM_011542272 XP_011540574 XM_011542273 XP_011540575 XR_946778 NM_001229 NP_001220 NM_001278054 NP_001264983 NM_032996 NP_127463 NR_102732 NR_102733
Function Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf- 1 leads to activation of the protease which then cleaves and activates caspase-3. Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP- ribose) polymerase (PARP).
Tissue Specificity Ubiquitous, with highest expression in the heart, moderate expression in liver, skeletal muscle, and pancreas. Low levels in all other tissues. Within the heart, specifically expressed in myocytes. {ECO:0000269|PubMed:16857965}.
Top Pathways Influenza A, p53 signaling pathway, VEGF signaling pathway, PI3K-Akt signaling pathway, Small cell lung cancer

caspase-9 CRISPR/Cas9 KO Plasmid (h) - sc-400257 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

caspase-9 HDR Plasmid (h) - sc-400257-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

caspase-9 Double Nickase Plasmid (h) - sc-400257-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

caspase-9 Double Nickase Plasmid (h2) - sc-400257-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

caspase-9 CRISPR Activation Plasmid (h) - sc-400257-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

caspase-9 CRISPR Activation Plasmid (h2) - sc-400257-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

caspase-9 Lentiviral Activation Particles (h) - sc-400257-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

caspase-9 Lentiviral Activation Particles (h2) - sc-400257-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

caspase-9 siRNA (h) - sc-29931 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

caspase-9 shRNA Plasmid (h) - sc-29931-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

caspase-9 shRNA (h) Lentiviral Particles - sc-29931-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Caspase-9 RNAi - H00000842-R01 from Novus Biologicals

Category siRNA
Prices $409.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU073601 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN1969 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1969 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR05713 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr05713

CASP9 siRNA (Human) - CRH0596 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

Caspase-9 RNAi - H00000842-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

CASP9 - MBS8237057 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human CASP9 (NM_001229.3) - SHH255049 from Creative biogene

Category siRNA
Species Reactivities Human

Human CASP9 siRNA - orb261098 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

CASP9 shRNA Plasmid (Human) - CHH0596 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

CASP9 miRNA 3'UTR clone - MiUTR3H-04799 from Creative biogene

Species Reactivities Human

CASP9 miRNA 3'UTR clone - MiUTR3H-04800 from Creative biogene

Species Reactivities Human
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