Gene Symbol | ABCE1 |
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Entrez Gene | 6059 |
Alt Symbol | ABC38, OABP, RLI, RNASEL1, RNASELI, RNS4I |
Species | Human |
Gene Type | protein-coding |
Description | ATP-binding cassette, sub-family E (OABP), member 1 |
Other Description | 2'-5'-oligoadenylate-binding protein|ATP-binding cassette sub-family E member 1|RNase L inhibitor|huHP68|ribonuclease 4 inhibitor|ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent) inhibitor |
Swissprots | Q6NR76 P61221 |
Accessions | AAZ38723 EAX05049 P61221 AB062293 BAB93476 AK123593 AK315198 BC016283 AAH16283 BC016988 AAH16988 BT009779 AAP88781 DA218189 X74987 CAA52920 X76388 CAA53972 NM_001040876 NP_001035809 NM_002940 NP_002931 |
Function | Antagonizes the binding of 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) by RNase L through direct interaction with RNase L and therefore inhibits its endoribonuclease activity. May play a central role in the regulation of mRNA turnover. Antagonizes the anti-viral effect of the interferon-regulated 2-5A/RNase L pathway. May act as a chaperone for post-translational events during HIV-1 capsid assembly. {ECO:0000269|PubMed:11585831, ECO:0000269|PubMed:9660177, ECO:0000269|PubMed:9847332}. |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:11585831}. Mitochondrion {ECO:0000269|PubMed:11585831}. Note=Localized to clusters of virus formation at the plasma membrane. |
ABCE1 (N-12) - sc-49338 from Santa Cruz Biotechnology
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ABCE1 (H-105) - sc-99064 from Santa Cruz Biotechnology
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ABCE1 (L-19) - sc-49337 from Santa Cruz Biotechnology
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Anti-ABCE1 antibody - ab117997 from Abcam
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Anti-ABCE1 antibody - ab123727 from Abcam
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Anti-ABCE1 antibody [EPR15373(B)] - C-terminal - ab185548 from Abcam
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Anti-ABCE1 Antibody (aa566-595, AP) - LS-C232313 from LifeSpan Bioscience
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Anti-ABCE1 Antibody (aa566-595, FITC) - LS-C232315 from LifeSpan Bioscience
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Anti-ABCE1 Antibody (aa566-595, PE) - LS-C232316 from LifeSpan Bioscience
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Anti-ABCE1 Antibody (aa566-595) - LS-C319244 from LifeSpan Bioscience
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Anti-ABCE1 Antibody (aa12-25) - LS-C87323 from LifeSpan Bioscience
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Anti-ABCE1 Antibody (aa1-119, Biotin) - LS-C142157 from LifeSpan Bioscience
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Anti-ABCE1 Antibody - LS-C137429 from LifeSpan Bioscience
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Anti-ABCE1 Antibody (aa1-119) - LS-C2755 from LifeSpan Bioscience
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Anti-ABCE1 Antibody (aa579-590) - LS-C54433 from LifeSpan Bioscience
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Anti-ABCE1 Antibody (aa1-119, DY650) - LS-C142158 from LifeSpan Bioscience
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Anti-ABCE1 Antibody (C-Terminus) - LS-C80599 from LifeSpan Bioscience
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Anti-ABCE1 Antibody (aa1-119, HRP) - LS-C142160 from LifeSpan Bioscience
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Anti-ABCE1 Antibody (aa1-119, DY488) - LS-C142159 from LifeSpan Bioscience
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Anti-ABCE1 Antibody (aa1-119, DY550) - LS-C142161 from LifeSpan Bioscience
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Anti-ABCE1 Antibody (aa566-595, APC) - LS-C232312 from LifeSpan Bioscience
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ABCE1 Antibody - NB400-116 from Novus Biologicals
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ABCE1 Antibody - NBP2-15225 from Novus Biologicals
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ABCE1 Antibody - NB100-94888 from Novus Biologicals
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ABCE1 Antibody [FITC] - NB400-116F from Novus Biologicals
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