Gene Symbol | ABCE1 |
---|---|
Entrez Gene | 6059 |
Alt Symbol | ABC38, OABP, RLI, RNASEL1, RNASELI, RNS4I |
Species | Human |
Gene Type | protein-coding |
Description | ATP-binding cassette, sub-family E (OABP), member 1 |
Other Description | 2'-5'-oligoadenylate-binding protein|ATP-binding cassette sub-family E member 1|RNase L inhibitor|huHP68|ribonuclease 4 inhibitor|ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent) inhibitor |
Swissprots | Q6NR76 P61221 |
Accessions | AAZ38723 EAX05049 P61221 AB062293 BAB93476 AK123593 AK315198 BC016283 AAH16283 BC016988 AAH16988 BT009779 AAP88781 DA218189 X74987 CAA52920 X76388 CAA53972 NM_001040876 NP_001035809 NM_002940 NP_002931 |
Function | Antagonizes the binding of 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) by RNase L through direct interaction with RNase L and therefore inhibits its endoribonuclease activity. May play a central role in the regulation of mRNA turnover. Antagonizes the anti-viral effect of the interferon-regulated 2-5A/RNase L pathway. May act as a chaperone for post-translational events during HIV-1 capsid assembly. {ECO:0000269|PubMed:11585831, ECO:0000269|PubMed:9660177, ECO:0000269|PubMed:9847332}. |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:11585831}. Mitochondrion {ECO:0000269|PubMed:11585831}. Note=Localized to clusters of virus formation at the plasma membrane. |
ABCE1 CRISPR/Cas9 KO Plasmid (h) - sc-407729 from Santa Cruz Biotechnology
|
||||||||
ABCE1 HDR Plasmid (h) - sc-407729-HDR from Santa Cruz Biotechnology
|
||||||||
ABCE1 Double Nickase Plasmid (h) - sc-407729-NIC from Santa Cruz Biotechnology
|
||||||||
ABCE1 Double Nickase Plasmid (h2) - sc-407729-NIC-2 from Santa Cruz Biotechnology
|
||||||||
ABCE1 CRISPR Activation Plasmid (h) - sc-407729-ACT from Santa Cruz Biotechnology
|
||||||||
ABCE1 CRISPR Activation Plasmid (h2) - sc-407729-ACT-2 from Santa Cruz Biotechnology
|
||||||||
ABCE1 Lentiviral Activation Particles (h) - sc-407729-LAC from Santa Cruz Biotechnology
|
||||||||
ABCE1 Lentiviral Activation Particles (h2) - sc-407729-LAC-2 from Santa Cruz Biotechnology
|
||||||||
ABCE1 siRNA (h) - sc-60117 from Santa Cruz Biotechnology
|
||||||||
ABCE1 shRNA Plasmid (h) - sc-60117-SH from Santa Cruz Biotechnology
|
||||||||
ABCE1 shRNA (h) Lentiviral Particles - sc-60117-V from Santa Cruz Biotechnology
|
||||||||
ABCE1 RNAi - H00006059-R02 from Novus Biologicals
|
||||||||
MISSION® esiRNA - EHU112211 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN2644 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2644 from Sigma-Aldrich
|
||||||||
ABCE1 siRNA (Human) - CRH4099 from Cohesion Biosciences
|
||||||||
ABCE1 - MBS8205744 from MyBioSource
|
||||||||
shRNA set against Human ABCE1(NM_001040876.1) - SHG024841 from Creative biogene
|
||||||||
Human ABCE1 siRNA - orb264601 from Biorbyt
|
||||||||
ABCE1 shRNA Plasmid (Human) - CHH4099 from Cohesion Biosciences
|
||||||||
ABCE1 miRNA 3'UTR clone - MiUTR1H-00047 from Creative biogene
|
||||||||
ABCE1 miRNA 3'UTR clone - MiUTR3H-03960 from Creative biogene
|