Gene Symbol | ABCE1 |
---|---|
Entrez Gene | 6059 |
Alt Symbol | ABC38, OABP, RLI, RNASEL1, RNASELI, RNS4I |
Species | Human |
Gene Type | protein-coding |
Description | ATP-binding cassette, sub-family E (OABP), member 1 |
Other Description | 2'-5'-oligoadenylate-binding protein|ATP-binding cassette sub-family E member 1|RNase L inhibitor|huHP68|ribonuclease 4 inhibitor|ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent) inhibitor |
Swissprots | Q6NR76 P61221 |
Accessions | AAZ38723 EAX05049 P61221 AB062293 BAB93476 AK123593 AK315198 BC016283 AAH16283 BC016988 AAH16988 BT009779 AAP88781 DA218189 X74987 CAA52920 X76388 CAA53972 NM_001040876 NP_001035809 NM_002940 NP_002931 |
Function | Antagonizes the binding of 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) by RNase L through direct interaction with RNase L and therefore inhibits its endoribonuclease activity. May play a central role in the regulation of mRNA turnover. Antagonizes the anti-viral effect of the interferon-regulated 2-5A/RNase L pathway. May act as a chaperone for post-translational events during HIV-1 capsid assembly. {ECO:0000269|PubMed:11585831, ECO:0000269|PubMed:9660177, ECO:0000269|PubMed:9847332}. |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:11585831}. Mitochondrion {ECO:0000269|PubMed:11585831}. Note=Localized to clusters of virus formation at the plasma membrane. |