Gene Symbol | TULP3 |
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Entrez Gene | 7289 |
Alt Symbol | TUBL3 |
Species | Human |
Gene Type | protein-coding |
Description | tubby like protein 3 |
Other Description | tubby-like protein 3|tubby-related protein 3 |
Swissprots | F8WBZ9 B7Z6A2 O75386 Q8N5B0 D3DUQ4 B3KNB7 |
Accessions | EAW88876 EAW88877 EAW88878 O75386 AF045583 AAC95431 AK024246 BAG51279 AK293285 BAH11483 AK307434 BC019618 BC032587 AAH32587 BP392987 EU446713 ABZ92242 JF432804 ADZ16021 NM_001160408 NP_001153880 NM_003324 NP_003315 |
Function | Negative regulator of the Shh signaling transduction pathway: recruited to primary cilia via association with the IFT complex A (IFT-A) and is required for recruitment of G protein- coupled receptor GPR161 to cilia, a promoter of PKA-dependent basal repression machinery in Shh signaling. Binds to phosphorylated inositide (phosphoinositide) lipids. Both IFT-A- and phosphoinositide-binding properties are required to regulate ciliary G protein-coupled receptor trafficking. Not involved in ciliogenesis. {ECO:0000269|PubMed:11375483, ECO:0000269|PubMed:20889716}. |
Subcellular Location | Nucleus. Cell membrane. Cell projection, cilium. Cytoplasm {ECO:0000250}. Secreted {ECO:0000250}. Note=Does not have a cleavable signal peptide and is secreted by a non- conventional pathway (By similarity). Translocates from the plasma membrane to the nucleus upon activation of guanine nucleotide- binding protein G(q) subunit alpha. {ECO:0000250}. |
Tissue Specificity | Expressed at high levels in testis, ovaries, thyroid, and spinal chord. {ECO:0000269|PubMed:9828123}. |
TULP3 (H-300) - sc-366166 from Santa Cruz Biotechnology
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TULP3 (H-10) - sc-393411 from Santa Cruz Biotechnology
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TULP3 (N-18) - sc-13479 from Santa Cruz Biotechnology
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TULP3 (P-18) - sc-23511 from Santa Cruz Biotechnology
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Anti-TULP3 antibody - ab155317 from Abcam
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Anti-TULP3 antibody - ab67624 from Abcam
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Anti-TULP3 antibody - C-terminal - ab138816 from Abcam
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Anti-TULP3 Antibody (clone 6H4) - LS-C173667 from LifeSpan Bioscience
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Anti-TULP3 Antibody (clone 1A10) - LS-C173665 from LifeSpan Bioscience
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Anti-TULP3 Antibody (clone 6C7) - LS-C337617 from LifeSpan Bioscience
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Anti-TULP3 Antibody (clone 6D8) - LS-C337600 from LifeSpan Bioscience
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Anti-TULP3 Antibody (aa216-265) - LS-C80057 from LifeSpan Bioscience
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Anti-TULP3 Antibody (aa374-400, AP) - LS-C242316 from LifeSpan Bioscience
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Anti-TULP3 Antibody (aa36-85) - LS-C80199 from LifeSpan Bioscience
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Anti-TULP3 Antibody (aa374-400, APC) - LS-C242318 from LifeSpan Bioscience
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Anti-TULP3 Antibody (aa374-400, Biotin) - LS-C242319 from LifeSpan Bioscience
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Anti-TULP3 Antibody (aa374-400, FITC) - LS-C242320 from LifeSpan Bioscience
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Anti-TULP3 Antibody (aa374-400, PE) - LS-C242322 from LifeSpan Bioscience
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Anti-TULP3 Antibody (aa374-400) - LS-C157299 from LifeSpan Bioscience
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Anti-TULP3 Antibody (aa374-400, Azide-free, HRP) - LS-C247168 from LifeSpan Bioscience
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Anti-TULP3 Antibody (aa374-400) - LS-C326104 from LifeSpan Bioscience
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Anti-TULP3 Antibody (clone 7B8) - LS-C173670 from LifeSpan Bioscience
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Anti-TULP3 Antibody (clone 4E5) - LS-C173666 from LifeSpan Bioscience
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TULP3 Antibody (7B8) - NBP2-01671 from Novus Biologicals
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TULP3 Antibody - NBP1-86897 from Novus Biologicals
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