| Gene Symbol | TULP3 |
|---|---|
| Entrez Gene | 7289 |
| Alt Symbol | TUBL3 |
| Species | Human |
| Gene Type | protein-coding |
| Description | tubby like protein 3 |
| Other Description | tubby-like protein 3|tubby-related protein 3 |
| Swissprots | F8WBZ9 B7Z6A2 O75386 Q8N5B0 D3DUQ4 B3KNB7 |
| Accessions | EAW88876 EAW88877 EAW88878 O75386 AF045583 AAC95431 AK024246 BAG51279 AK293285 BAH11483 AK307434 BC019618 BC032587 AAH32587 BP392987 EU446713 ABZ92242 JF432804 ADZ16021 NM_001160408 NP_001153880 NM_003324 NP_003315 |
| Function | Negative regulator of the Shh signaling transduction pathway: recruited to primary cilia via association with the IFT complex A (IFT-A) and is required for recruitment of G protein- coupled receptor GPR161 to cilia, a promoter of PKA-dependent basal repression machinery in Shh signaling. Binds to phosphorylated inositide (phosphoinositide) lipids. Both IFT-A- and phosphoinositide-binding properties are required to regulate ciliary G protein-coupled receptor trafficking. Not involved in ciliogenesis. {ECO:0000269|PubMed:11375483, ECO:0000269|PubMed:20889716}. |
| Subcellular Location | Nucleus. Cell membrane. Cell projection, cilium. Cytoplasm {ECO:0000250}. Secreted {ECO:0000250}. Note=Does not have a cleavable signal peptide and is secreted by a non- conventional pathway (By similarity). Translocates from the plasma membrane to the nucleus upon activation of guanine nucleotide- binding protein G(q) subunit alpha. {ECO:0000250}. |
| Tissue Specificity | Expressed at high levels in testis, ovaries, thyroid, and spinal chord. {ECO:0000269|PubMed:9828123}. |