| Gene Symbol |
MBD3
|
| Entrez Gene |
53615
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
methyl-CpG binding domain protein 3
|
| Other Description |
methyl-CpG-binding domain protein 3
|
| Swissprots |
Q86XF4 Q6PJZ9 D6W5Z2 O95983 A8K4B7 Q6PIL9
|
| Accessions |
AAC72104 EAW69477 EAW69478 EAW69479 EAW69480 EAW69481 O95983 AA576859 AF072247 AAC68876 AK001474 BAG50920 AK021532 AK092508 AK290882 BAF83571 AL390153 BC000872 BC009372 AAH09372 BC009438 AAH09438 BC018784 AAH18784 BC032443 AAH32443 BC043619 AAH43619 BM684485 BU181763 X58233 CAA41191 NM_001281453 NP_001268382 NM_001281454 NP_001268383 NM_003926
|
| Function |
Acts as transcriptional repressor and plays a role in gene silencing. Does not bind to DNA by itself (PubMed:12124384). Binds to DNA with a preference for sites containing methylated CpG dinucleotides (in vitro). Binds to a lesser degree DNA containing unmethylated CpG dinucleotides (PubMed:24307175). Recruits histone deacetylases and DNA methyltransferases. {ECO:0000269|PubMed:10947852, ECO:0000269|PubMed:12124384, ECO:0000269|PubMed:18644863, ECO:0000269|PubMed:23361464, ECO:0000269|PubMed:24307175, ECO:0000269|PubMed:9774669}.
|
| Subcellular Location |
Nucleus. Chromosome. Note=Nuclear, in discrete foci. Detected on chromatin, at promoter regions of active genes.
|