Gene Symbol | CCBL2 |
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Entrez Gene | 56267 |
Alt Symbol | KAT3, KATIII |
Species | Human |
Gene Type | protein-coding |
Description | cysteine conjugate-beta lyase 2 |
Other Description | RP11-82K18.3|cysteine-S-conjugate beta-lyase 2|kynurenine aminotransferase III|kynurenine--glyoxylate transaminase|kynurenine--oxoglutarate transaminase 3|kynurenine--oxoglutarate transaminase III|kynurenine-oxoglutarate transaminase 3 |
Swissprots | Q5T9T7 Q6YP21 B3KQ13 O95335 Q5JS27 Q5T9T8 Q6ICW1 Q9BVY5 Q6AI27 |
Accessions | EAW73154 EAW73157 EAW73158 Q6YP21 AF091090 AAC72959 AI478599 AK057176 BAG51875 AK301326 BAG62875 AK315917 BAH14288 AL833593 AY028624 AAK26163 BC000819 AAH00819 BM728982 CR450282 CAG29278 CR627392 CAH10487 DC424120 NM_001008661 NP_001008661 NM_001008662 NP_001008662 |
Function | Catalyzes the irreversible transamination of the L- tryptophan metabolite L-kynurenine to form kynurenic acid (KA). May catalyze the beta-elimination of S-conjugates and Se- conjugates of L-(seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond (By similarity). Has transaminase activity towards L-kynurenine, tryptophan, phenylalanine, serine, cysteine, methionine, histidine, glutamine and asparagine with glyoxylate as an amino group acceptor (in vitro). Has lower activity with 2- oxoglutarate as amino group acceptor (in vitro) (By similarity). {ECO:0000250}. |
Top Pathways | Chemical carcinogenesis, Selenocompound metabolism, Tryptophan metabolism |
KAT III CRISPR/Cas9 KO Plasmid (h) - sc-412701 from Santa Cruz Biotechnology
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KAT III HDR Plasmid (h) - sc-412701-HDR from Santa Cruz Biotechnology
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KAT III Double Nickase Plasmid (h) - sc-412701-NIC from Santa Cruz Biotechnology
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KAT III Double Nickase Plasmid (h2) - sc-412701-NIC-2 from Santa Cruz Biotechnology
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KAT III CRISPR Activation Plasmid (h) - sc-412701-ACT from Santa Cruz Biotechnology
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KAT III CRISPR Activation Plasmid (h2) - sc-412701-ACT-2 from Santa Cruz Biotechnology
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KAT III Lentiviral Activation Particles (h) - sc-412701-LAC from Santa Cruz Biotechnology
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KAT III Lentiviral Activation Particles (h2) - sc-412701-LAC-2 from Santa Cruz Biotechnology
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KAT III siRNA (h) - sc-105589 from Santa Cruz Biotechnology
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KAT III shRNA Plasmid (h) - sc-105589-SH from Santa Cruz Biotechnology
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KAT III shRNA (h) Lentiviral Particles - sc-105589-V from Santa Cruz Biotechnology
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CCBL2 RNAi - H00056267-R02 from Novus Biologicals
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CCBL2 RNAi - H00056267-R01 from Novus Biologicals
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MISSION® esiRNA - EHU095691 from Sigma-Aldrich
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MISSION® esiRNA - EHU108481 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN5442 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5442 from Sigma-Aldrich
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CCBL2 siRNA (Human) - CRJ1126 from Cohesion Biosciences
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CCBL2 - MBS8204706 from MyBioSource
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shRNA set against Human CCBL2 (NM_001008661.2) - SHH255681 from Creative biogene
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Human CCBL2 siRNA - orb271627 from Biorbyt
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CCBL2 shRNA Plasmid (Human) - CHJ1126 from Cohesion Biosciences
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CCBL2 miRNA 3'UTR clone - MiUTR3H-11390 from Creative biogene
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CCBL2 miRNA 3'UTR clone - MiUTR3H-11391 from Creative biogene
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