| Gene Symbol |
LEF1
|
| Entrez Gene |
51176
|
| Alt Symbol |
LEF-1, TCF10, TCF1ALPHA, TCF7L3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
lymphoid enhancer-binding factor 1
|
| Other Description |
T cell-specific transcription factor 1-alpha|TCF1-alpha
|
| Swissprots |
B4DG38 Q9UJU2 Q3ZCU4 B7Z8E2 E9PDK3 Q9HAZ0
|
| Accessions |
AAK64602 AAN06089 AEW16365 EAX06221 EAX06222 EAX06223 EAX06224 EAX06225 Q9UJU2 AF086339 AF198532 AAF13268 AF288571 AAG01022 AF294627 AAG26886 AK128255 AK225772 AK294395 BAG57649 AK303143 BAG64247 AK303272 BAH13928 AL049409 CAH56421 BC040559 AAH40559 BC050632 AAH50632 DC405840 DC406065 EU446873 ABZ92402 XM_005263046 XP_005263103 XM_005263047 XP_005263104 XM_005263048 XP_005263105 XM_006714233 XP_006714296 NM_001130713 NP_001124185 NM_001130714 NP_001124186 NM_001166119 NP_001159591 NM_016269 NP_057353
|
| Function |
Participates in the Wnt signaling pathway. Activates transcription of target genes in the presence of CTNNB1 and EP300. May play a role in hair cell differentiation and follicle morphogenesis. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by LEF1 and CTNNB1. Regulates T-cell receptor alpha enhancer function. Binds DNA in a sequence-specific manner. PIAG antagonizes both Wnt-dependent and Wnt-independent activation by LEF1 (By similarity). Isoform 3 lacks the CTNNB1 interaction domain and may be an antagonist for Wnt signaling. Isoform 5 transcriptionally activates the fibronectin promoter, binds to and represses transcription from the E-cadherin promoter in a CTNNB1- independent manner, and is involved in reducing cellular aggregation and increasing cell migration of pancreatic cancer cells. Isoform 1 transcriptionally activates MYC and CCND1 expression and enhances proliferation of pancreatic tumor cells. {ECO:0000250, ECO:0000269|PubMed:11266540, ECO:0000269|PubMed:19653
|
| Subcellular Location |
Nucleus {ECO:0000255|PROSITE- ProRule:PRU00267}. Note=Found in nuclear bodies upon PIASG binding. {ECO:0000250}.
|
| Tissue Specificity |
Detected in thymus. Not detected in normal colon, but highly expressed in colon cancer biopsies and colon cancer cell lines. Expressed in several pancreatic tumors and weakly expressed in normal pancreatic tissue. Isoforms 1 and 5 are detected in several pancreatic cell lines. {ECO:0000269|PubMed:19653274}.
|
| Top Pathways |
Hippo signaling pathway, Wnt signaling pathway, Arrhythmogenic right ventricular cardiomyopathy (ARVC), Thyroid cancer, Prostate cancer
|
