LEF1

Gene Symbol	LEF1
Entrez Gene	51176
Alt Symbol	LEF-1, TCF10, TCF1ALPHA, TCF7L3
Species	Human
Gene Type	protein-coding
Description	lymphoid enhancer-binding factor 1
Other Description	T cell-specific transcription factor 1-alpha|TCF1-alpha
Swissprots	B4DG38 Q9UJU2 Q3ZCU4 B7Z8E2 E9PDK3 Q9HAZ0
Accessions	AAK64602 AAN06089 AEW16365 EAX06221 EAX06222 EAX06223 EAX06224 EAX06225 Q9UJU2 AF086339 AF198532 AAF13268 AF288571 AAG01022 AF294627 AAG26886 AK128255 AK225772 AK294395 BAG57649 AK303143 BAG64247 AK303272 BAH13928 AL049409 CAH56421 BC040559 AAH40559 BC050632 AAH50632 DC405840 DC406065 EU446873 ABZ92402 XM_005263046 XP_005263103 XM_005263047 XP_005263104 XM_005263048 XP_005263105 XM_006714233 XP_006714296 NM_001130713 NP_001124185 NM_001130714 NP_001124186 NM_001166119 NP_001159591 NM_016269 NP_057353
Function	Participates in the Wnt signaling pathway. Activates transcription of target genes in the presence of CTNNB1 and EP300. May play a role in hair cell differentiation and follicle morphogenesis. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by LEF1 and CTNNB1. Regulates T-cell receptor alpha enhancer function. Binds DNA in a sequence-specific manner. PIAG antagonizes both Wnt-dependent and Wnt-independent activation by LEF1 (By similarity). Isoform 3 lacks the CTNNB1 interaction domain and may be an antagonist for Wnt signaling. Isoform 5 transcriptionally activates the fibronectin promoter, binds to and represses transcription from the E-cadherin promoter in a CTNNB1- independent manner, and is involved in reducing cellular aggregation and increasing cell migration of pancreatic cancer cells. Isoform 1 transcriptionally activates MYC and CCND1 expression and enhances proliferation of pancreatic tumor cells. {ECO:0000250, ECO:0000269|PubMed:11266540, ECO:0000269|PubMed:19653
Subcellular Location	Nucleus {ECO:0000255|PROSITE- ProRule:PRU00267}. Note=Found in nuclear bodies upon PIASG binding. {ECO:0000250}.
Tissue Specificity	Detected in thymus. Not detected in normal colon, but highly expressed in colon cancer biopsies and colon cancer cell lines. Expressed in several pancreatic tumors and weakly expressed in normal pancreatic tissue. Isoforms 1 and 5 are detected in several pancreatic cell lines. {ECO:0000269|PubMed:19653274}.
Top Pathways	Hippo signaling pathway, Wnt signaling pathway, Arrhythmogenic right ventricular cardiomyopathy (ARVC), Thyroid cancer, Prostate cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human LEF1 full length protein - ab132092 from Abcam Category Protein Source Wheat germ Species Human

Human LEF1 peptide - ab95919 from Abcam Category Peptide

Human LEF1 protein fragment - ab153336 from Abcam Category Protein Source Wheat germ Species Human

Human LEF1 protein fragment - ab153337 from Abcam Category Protein Source Wheat germ Species Human

LEF1 Antibody Blocking Peptide - LS-E1392 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

LEF1 Antibody Blocking Peptide - LS-E10896 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

LEF1 Antibody Blocking Peptide - LS-E11347 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

LEF1 Antibody Blocking Peptide - LS-E26071 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human LEF1 Protein - H00051176-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human LEF1 Protein - H00051176-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human LEF1 Protein - H00051176-Q03 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

LEF1-Antibody-N-term-Blocking-peptide - BP12048a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

LEF1 blocking peptide - GTX89284-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Rat

LEF1 Protein Lysate (APL10358) - APL10358 from Aviva Systems Biology Category Protein Prices $219.00 Sizes 200 µg

LEF1 Protein Lysate (APL10567) - APL10567 from Aviva Systems Biology Category Protein Prices $219.00 Sizes 200 µg

LEF1 Peptide - AC21-0899-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

LEF1 - H00051176-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

LEF1 - H00051176-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

LEF1 - H00051176-Q03-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

LEF1 - H00051176-Q03-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

LEF1 Peptide - 45-083P from ProSci Category Peptide Prices $175.00 Sizes 100 µg Species Human, Mouse, Rat

LEF1 fusion protein - Ag6882 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant Human LEF1, His-tagged - LEF1-540H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human Lymphoid enhancer-binding factor 1(LEF1) - CSB-YP012856HU CSB-EP012856HU CSB-BP012856HU CSB-MP012856HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

LEF1 (full length, N-term HIS tag) - TP760177 from Acris Antibodies Category Protein Prices $199.00 Sizes 50 µg Source E. coli Species Human

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