LEF1

Gene Symbol	LEF1
Entrez Gene	51176
Alt Symbol	LEF-1, TCF10, TCF1ALPHA, TCF7L3
Species	Human
Gene Type	protein-coding
Description	lymphoid enhancer-binding factor 1
Other Description	T cell-specific transcription factor 1-alpha|TCF1-alpha
Swissprots	B4DG38 Q9UJU2 Q3ZCU4 B7Z8E2 E9PDK3 Q9HAZ0
Accessions	AAK64602 AAN06089 AEW16365 EAX06221 EAX06222 EAX06223 EAX06224 EAX06225 Q9UJU2 AF086339 AF198532 AAF13268 AF288571 AAG01022 AF294627 AAG26886 AK128255 AK225772 AK294395 BAG57649 AK303143 BAG64247 AK303272 BAH13928 AL049409 CAH56421 BC040559 AAH40559 BC050632 AAH50632 DC405840 DC406065 EU446873 ABZ92402 XM_005263046 XP_005263103 XM_005263047 XP_005263104 XM_005263048 XP_005263105 XM_006714233 XP_006714296 NM_001130713 NP_001124185 NM_001130714 NP_001124186 NM_001166119 NP_001159591 NM_016269 NP_057353
Function	Participates in the Wnt signaling pathway. Activates transcription of target genes in the presence of CTNNB1 and EP300. May play a role in hair cell differentiation and follicle morphogenesis. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by LEF1 and CTNNB1. Regulates T-cell receptor alpha enhancer function. Binds DNA in a sequence-specific manner. PIAG antagonizes both Wnt-dependent and Wnt-independent activation by LEF1 (By similarity). Isoform 3 lacks the CTNNB1 interaction domain and may be an antagonist for Wnt signaling. Isoform 5 transcriptionally activates the fibronectin promoter, binds to and represses transcription from the E-cadherin promoter in a CTNNB1- independent manner, and is involved in reducing cellular aggregation and increasing cell migration of pancreatic cancer cells. Isoform 1 transcriptionally activates MYC and CCND1 expression and enhances proliferation of pancreatic tumor cells. {ECO:0000250, ECO:0000269|PubMed:11266540, ECO:0000269|PubMed:19653
Subcellular Location	Nucleus {ECO:0000255|PROSITE- ProRule:PRU00267}. Note=Found in nuclear bodies upon PIASG binding. {ECO:0000250}.
Tissue Specificity	Detected in thymus. Not detected in normal colon, but highly expressed in colon cancer biopsies and colon cancer cell lines. Expressed in several pancreatic tumors and weakly expressed in normal pancreatic tissue. Isoforms 1 and 5 are detected in several pancreatic cell lines. {ECO:0000269|PubMed:19653274}.
Top Pathways	Hippo signaling pathway, Wnt signaling pathway, Arrhythmogenic right ventricular cardiomyopathy (ARVC), Thyroid cancer, Prostate cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human LEF1 gene - orb92912 from Biorbyt Prices $306.00 Sizes 10 μg Species Human

Human-LEF1-cDNA-Clone - DC07824 from Abgent, a WuXi AppTec company Prices $538.65 Sizes 10 µg Species Human Accession BC050632

LEF1 cDNA (ANA10358) - ANA10358 from Aviva Systems Biology Prices $189.00 Sizes 1 µg Accession BC050632

LEF1 cDNA (ANA10567) - ANA10567 from Aviva Systems Biology Prices $189.00 Sizes 1 µg Accession BC050632

LEF1 - MBS1272776 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC050632

Human LEF1 cDNA clone(NM_001166119.1) - CDFH010292 from Creative Biomart Species Human Accession NM_001166119.1

Human LEF1 ORF Clone(NM_001166119.1) - CDCR355195 from Creative Biomart Species Human Accession NM_001166119.1

Human LEF1 ORF Clone(NM_001166119.1) - CDCR355197 from Creative Biomart Species Human Accession NM_001166119.1

Human LEF1 ORF Clone(NM_016269.4) - CDCL168563 from Creative Biomart Species Human Accession NM_016269.4

Human LEF1 ORF Clone(NM_001130713.2) - CDCL168564 from Creative Biomart Species Human Accession NM_001130713.2

Human LEF1 ORF clone(NM_016269.4) - CDCL185121 from Creative Biomart Species Human Accession NM_016269.4

Human LEF1 Gene ORF cDNA clone in cloning vector - HG12090-G from Sino Biological Species Human

Human LEF1 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG12090-CM from Sino Biological Species Human

Human LEF1 Gene ORF cDNA clone expression plasmid, C-HA tag - HG12090-CY from Sino Biological Species Human

Human LEF1 Gene ORF cDNA clone expression plasmid, N-GFPSpark tag - HG12090-ANG from Sino Biological Species Human

Human LEF1 Gene ORF cDNA clone expression plasmid - HG12090-UT from Sino Biological Species Human

Human LEF1 Gene ORF cDNA clone expression plasmid, N-HA tag - HG12090-NY from Sino Biological Species Human

Human LEF1 Gene ORF cDNA clone expression plasmid, N-His tag - HG12090-NH from Sino Biological Species Human

Human LEF1 Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG12090-ACR from Sino Biological Species Human

Human LEF1 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG12090-NF from Sino Biological Species Human

Human LEF1 Gene ORF cDNA clone expression plasmid, N-OFPSpark tag - HG12090-ANR from Sino Biological Species Human

Human LEF1 Gene ORF cDNA clone expression plasmid, C-His tag - HG12090-CH from Sino Biological Species Human

Human LEF1 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG12090-NM from Sino Biological Species Human

Human LEF1 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG12090-CF from Sino Biological Species Human

Human LEF1 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG12090-ACG from Sino Biological Species Human

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