SLC6A4

Gene Symbol	SLC6A4
Entrez Gene	6532
Alt Symbol	5-HTT, 5-HTTLPR, 5HTT, HTT, OCD1, SERT, SERT1, hSERT
Species	Human
Gene Type	protein-coding
Description	solute carrier family 6 (neurotransmitter transporter), member 4
Other Description	5-hydroxytryptamine (serotonin) transporter\|5HT transporter\|Na+/Cl- dependent serotonin transporter\|serotonin transporter 1\|sodium-dependent serotonin transporter\|solute carrier family 6 (neurotransmitter transporter, serotonin), member 4
Swissprots	Q5EE02 P31645
Accessions	AAB26687 AAB93475 AAF61945 ABV02581 ACE96158 ACE96163 ACE96168 ACE96173 ACE96178 ACE96183 ACE96188 ACE96193 ACE96198 ACE96203 ACE96208 ACE96213 ACE96218 CAI53631 EAW51223 P31645 AA700070 AK308014 AK309538 AK313166 BAG35984 AU138385 AY902473 AAW80933 BC069484 AAH69484 BE645279 BQ017027 BX399758 DC345903 L05568 AAA35492 X70697 CAA50029 NM_001045 NP_001036
Function	Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner. {ECO:0000269\|PubMed:17506858, ECO:0000269\|PubMed:18227069, ECO:0000269\|PubMed:19270731}.
Subcellular Location	Cell membrane; Multi-pass membrane protein. Endomembrane system; Multi-pass membrane protein. Endosome membrane; Multi-pass membrane protein. Note=Translocates from intracellular locations to the plasma membrane. Density of transporter molecules on the plasma membrane is itself regulated by serotonin.
Tissue Specificity	Expressed in platelets (at protein level). {ECO:0000269\|PubMed:17506858}.

ST (C-20) - sc-1458 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

ST (C-20): sc-1458. Western blot analysis of ST expression in rat brain extract.

ST (H-115) - sc-13997 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Rabbit
Clonality	Polyclonal

ST (H-115): sc-13997. Western blot analysis of ST expression in rat brain tissue extract.

ST (I-21) - sc-14516 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

ST (N-14) - sc-14514 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

ST (N-14): sc-14514. Western blot analysis of ST expression in SCC-4 whole cell lysate.

ST (24A5) - sc-33724 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	100 µg/ml
Host	Mouse
Clonality	Monoclonal

ST (24A5): sc-33724. Western blot analysis of serotonin transporter expression in human (A) and rat (B) brain tissue extracts.

Anti-Serotonin transporter antibody - ab102048 from Abcam

Prices	$376.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-Serotonin transporter antibody (ab102048) at 1/500 dilution + Mouse lung tissue lysate at 50 µgdeveloped using the ECL technique

Anti-Serotonin transporter antibody - ab174770 from Abcam

Prices	$376.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

IHC image of Serotonin transporter staining in Human cerebral cortex formalin fixed paraffin embedded tissue section*, performed on a Leica Bond™ system using the standard protocol F. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH6, epitope retrieval solution 1) for 20 mins. The section was then incubated with ab174770, 1µg/ml, for 15 mins at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.For other IHC staining systems (automated and non-automated) customers should optimize variable parameters such as antigen retrieval conditions, primary antibody concentration and antibody incubation times.*Tissue obtained from the Human Research Tissue Bank, supported by the NIHR Cambridge Biomedical Research Centre

Anti-Serotonin transporter antibody - ab135846 from Abcam

Prices	$376.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-Serotonin transporter antibody (ab135846) at 1/500 dilution + extracts from Human brain tissue at 30 µg

Anti-Serotonin transporter antibody [EPR12735] - ab181034 from Abcam

Prices	$99.00, $378.00
Sizes	10 µl, 100 µl
Host	Rabbit
Clonality	Monoclonal
Clone	EPR12735

All lanes : Anti-Serotonin transporter antibody [EPR12735] (ab181034) at 1/1000 dilutionLane 1 : Human fetal liver lysateLane 2 : Human placenta lysateLane 3 : Human serum lysateLane 4 : Human plasma lysateLysates/proteins at 10 µg per lane.SecondaryStandard HRP-labeled goat anti-rabbit at 1/2000 dilutiondeveloped using the ECL technique

Anti-SLC6A4 / SERT Antibody (aa579-599) - LS-C39059 from LifeSpan Bioscience

Prices	$605.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Anti-SLC6A4 / SERT Antibody (aa634-653) - LS-C39060 from LifeSpan Bioscience

Prices	$445.00
Sizes	50 µl
Host	Guinea Pig
Clonality	Polyclonal

Anti-SLC6A4 / SERT Antibody (aa1-85) - LS-C39061 from LifeSpan Bioscience

Prices	$425.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal

Anti-SLC6A4 / SERT Antibody (Extracellular Domain) - LS-C39062 from LifeSpan Bioscience

Prices	$365.00
Sizes	50 µl
Host	Rabbit
Clonality	Polyclonal

Anti-SLC6A4 / SERT Antibody (Extracellular Domain) - LS-C39063 from LifeSpan Bioscience

Prices	$385.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Anti-SLC6A4 / SERT Antibody (aa1-85) - LS-C42146 from LifeSpan Bioscience

Prices	$885.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal

Anti-SLC6A4 / SERT Antibody (aa1-85, clone MAB1564) - LS-C85432 from LifeSpan Bioscience

Prices	$560.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	MAB1564

Anti-SLC6A4 / SERT Antibody - LS-C126270 from LifeSpan Bioscience

Prices	$465.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-SLC6A4 / SERT Antibody (aa1-630) - LS-C132054 from LifeSpan Bioscience

Prices	$465.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-SLC6A4 / SERT Antibody (clone 17-7A4) - LS-C180185 from LifeSpan Bioscience

Prices	$335.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	17-7A4

Anti-SLC6A4 / SERT Antibody (C-Terminus) - LS-C152826 from LifeSpan Bioscience

Prices	$345.00
Sizes	50 µl
Host	Guinea Pig
Clonality	Polyclonal

IHC: Guinea Pig anti-Serotonin Transporter (LS-C152826).

Anti-SLC6A4 / SERT Antibody (aa116-126) - LS-C55475 from LifeSpan Bioscience

Prices	$395.00
Sizes	100 µg
Host	Goat
Clonality	Polyclonal

Antibody staining (1 ug/ml) of Human Duodenum lysate (RIPA buffer, 30 ug total protein per lane). Primary incubated for 1 hour. Detected by Western blot of chemiluminescence.

Anti-SLC6A4 / SERT Antibody (aa7-24) - LS-C312854 from LifeSpan Bioscience

Prices	$305.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

WB of SLC6A4 / SERT antibody. Lane 1: U87 Cell Lysate. Lane 2: HELA Cell Lysate. Lane 3: JURKAT Cell Lysate.

Anti-SLC6A4 / SERT Antibody (clone 2A9) - LS-C198211 from LifeSpan Bioscience

Prices	$355.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	2A9

Detection limit for recombinant GST tagged SLC6A4 is approximately 0.3 ng/ml as a capture antibody.

Anti-SLC6A4 / SERT Antibody (aa348-397) - LS-C200013 from LifeSpan Bioscience

Prices	$315.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Western blot of extracts from brain tissue , using ST antibody.

Anti-SLC6A4 / SERT Antibody - LS-C179236 from LifeSpan Bioscience

Prices	$365.00
Sizes	50 µl
Host	Rabbit
Clonality	Polyclonal

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