SLC6A4

Gene Symbol SLC6A4
Entrez Gene 6532
Alt Symbol 5-HTT, 5-HTTLPR, 5HTT, HTT, OCD1, SERT, SERT1, hSERT
Species Human
Gene Type protein-coding
Description solute carrier family 6 (neurotransmitter transporter), member 4
Other Description 5-hydroxytryptamine (serotonin) transporter|5HT transporter|Na+/Cl- dependent serotonin transporter|serotonin transporter 1|sodium-dependent serotonin transporter|solute carrier family 6 (neurotransmitter transporter, serotonin), member 4
Swissprots Q5EE02 P31645
Accessions AAB26687 AAB93475 AAF61945 ABV02581 ACE96158 ACE96163 ACE96168 ACE96173 ACE96178 ACE96183 ACE96188 ACE96193 ACE96198 ACE96203 ACE96208 ACE96213 ACE96218 CAI53631 EAW51223 P31645 AA700070 AK308014 AK309538 AK313166 BAG35984 AU138385 AY902473 AAW80933 BC069484 AAH69484 BE645279 BQ017027 BX399758 DC345903 L05568 AAA35492 X70697 CAA50029 NM_001045 NP_001036
Function Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner. {ECO:0000269|PubMed:17506858, ECO:0000269|PubMed:18227069, ECO:0000269|PubMed:19270731}.
Subcellular Location Cell membrane; Multi-pass membrane protein. Endomembrane system; Multi-pass membrane protein. Endosome membrane; Multi-pass membrane protein. Note=Translocates from intracellular locations to the plasma membrane. Density of transporter molecules on the plasma membrane is itself regulated by serotonin.
Tissue Specificity Expressed in platelets (at protein level). {ECO:0000269|PubMed:17506858}.

Human SLC6A4/5-HTTLPR (NP_001036) VersaClone cDNA - RDC1060 from R&D Systems

Prices $499.00
Sizes 10 µg
Species Human

Human SLC6A4 ORF Clone(NM_001045.4) - CDCL176203 from Creative Biomart

Species Human
Accession NM_001045.4
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