SLC6A4

Gene Symbol SLC6A4
Entrez Gene 6532
Alt Symbol 5-HTT, 5-HTTLPR, 5HTT, HTT, OCD1, SERT, SERT1, hSERT
Species Human
Gene Type protein-coding
Description solute carrier family 6 (neurotransmitter transporter), member 4
Other Description 5-hydroxytryptamine (serotonin) transporter|5HT transporter|Na+/Cl- dependent serotonin transporter|serotonin transporter 1|sodium-dependent serotonin transporter|solute carrier family 6 (neurotransmitter transporter, serotonin), member 4
Swissprots Q5EE02 P31645
Accessions AAB26687 AAB93475 AAF61945 ABV02581 ACE96158 ACE96163 ACE96168 ACE96173 ACE96178 ACE96183 ACE96188 ACE96193 ACE96198 ACE96203 ACE96208 ACE96213 ACE96218 CAI53631 EAW51223 P31645 AA700070 AK308014 AK309538 AK313166 BAG35984 AU138385 AY902473 AAW80933 BC069484 AAH69484 BE645279 BQ017027 BX399758 DC345903 L05568 AAA35492 X70697 CAA50029 NM_001045 NP_001036
Function Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner. {ECO:0000269|PubMed:17506858, ECO:0000269|PubMed:18227069, ECO:0000269|PubMed:19270731}.
Subcellular Location Cell membrane; Multi-pass membrane protein. Endomembrane system; Multi-pass membrane protein. Endosome membrane; Multi-pass membrane protein. Note=Translocates from intracellular locations to the plasma membrane. Density of transporter molecules on the plasma membrane is itself regulated by serotonin.
Tissue Specificity Expressed in platelets (at protein level). {ECO:0000269|PubMed:17506858}.

ST CRISPR/Cas9 KO Plasmid (h) - sc-400733 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ST HDR Plasmid (h) - sc-400733-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ST Double Nickase Plasmid (h) - sc-400733-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ST Double Nickase Plasmid (h2) - sc-400733-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ST CRISPR Activation Plasmid (h) - sc-400733-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ST CRISPR Activation Plasmid (h2) - sc-400733-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ST Lentiviral Activation Particles (h) - sc-400733-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ST Lentiviral Activation Particles (h2) - sc-400733-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ST siRNA (h) - sc-36565 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

ST shRNA Plasmid (h) - sc-36565-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

ST shRNA (h) Lentiviral Particles - sc-36565-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

SLC6A4/5-HTTLPR/Serotonin transporter RNAi - H00006532-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU023771 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN1890 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

SLC6A4 siRNA (Human) - CRH4426 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SLC6A4 - MBS8218154 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human SLC6A4 (NM_001045.4) - SHH411960 from Creative biogene

Category siRNA
Species Reactivities Human

Human SLC6A4 siRNA - orb264928 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SLC6A4 shRNA Plasmid (Human) - CHH4426 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

SLC6A4 miRNA 3'UTR clone - MiUTR1H-09593 from Creative biogene

Species Reactivities Human
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