Gene Symbol | SLC6A4 |
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Entrez Gene | 6532 |
Alt Symbol | 5-HTT, 5-HTTLPR, 5HTT, HTT, OCD1, SERT, SERT1, hSERT |
Species | Human |
Gene Type | protein-coding |
Description | solute carrier family 6 (neurotransmitter transporter), member 4 |
Other Description | 5-hydroxytryptamine (serotonin) transporter|5HT transporter|Na+/Cl- dependent serotonin transporter|serotonin transporter 1|sodium-dependent serotonin transporter|solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 |
Swissprots | Q5EE02 P31645 |
Accessions | AAB26687 AAB93475 AAF61945 ABV02581 ACE96158 ACE96163 ACE96168 ACE96173 ACE96178 ACE96183 ACE96188 ACE96193 ACE96198 ACE96203 ACE96208 ACE96213 ACE96218 CAI53631 EAW51223 P31645 AA700070 AK308014 AK309538 AK313166 BAG35984 AU138385 AY902473 AAW80933 BC069484 AAH69484 BE645279 BQ017027 BX399758 DC345903 L05568 AAA35492 X70697 CAA50029 NM_001045 NP_001036 |
Function | Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner. {ECO:0000269|PubMed:17506858, ECO:0000269|PubMed:18227069, ECO:0000269|PubMed:19270731}. |
Subcellular Location | Cell membrane; Multi-pass membrane protein. Endomembrane system; Multi-pass membrane protein. Endosome membrane; Multi-pass membrane protein. Note=Translocates from intracellular locations to the plasma membrane. Density of transporter molecules on the plasma membrane is itself regulated by serotonin. |
Tissue Specificity | Expressed in platelets (at protein level). {ECO:0000269|PubMed:17506858}. |
ST CRISPR/Cas9 KO Plasmid (h) - sc-400733 from Santa Cruz Biotechnology
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ST HDR Plasmid (h) - sc-400733-HDR from Santa Cruz Biotechnology
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ST Double Nickase Plasmid (h) - sc-400733-NIC from Santa Cruz Biotechnology
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ST Double Nickase Plasmid (h2) - sc-400733-NIC-2 from Santa Cruz Biotechnology
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ST CRISPR Activation Plasmid (h) - sc-400733-ACT from Santa Cruz Biotechnology
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ST CRISPR Activation Plasmid (h2) - sc-400733-ACT-2 from Santa Cruz Biotechnology
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ST Lentiviral Activation Particles (h) - sc-400733-LAC from Santa Cruz Biotechnology
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ST Lentiviral Activation Particles (h2) - sc-400733-LAC-2 from Santa Cruz Biotechnology
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ST siRNA (h) - sc-36565 from Santa Cruz Biotechnology
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ST shRNA Plasmid (h) - sc-36565-SH from Santa Cruz Biotechnology
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ST shRNA (h) Lentiviral Particles - sc-36565-V from Santa Cruz Biotechnology
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SLC6A4/5-HTTLPR/Serotonin transporter RNAi - H00006532-R01 from Novus Biologicals
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MISSION® esiRNA - EHU023771 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN1890 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1890 from Sigma-Aldrich
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SLC6A4 siRNA (Human) - CRH4426 from Cohesion Biosciences
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SLC6A4 - MBS8218154 from MyBioSource
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shRNA set against Human SLC6A4 (NM_001045.4) - SHH411960 from Creative biogene
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Human SLC6A4 siRNA - orb264928 from Biorbyt
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SLC6A4 shRNA Plasmid (Human) - CHH4426 from Cohesion Biosciences
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SLC6A4 miRNA 3'UTR clone - MiUTR1H-09593 from Creative biogene
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