| Gene Symbol |
BLVRB
|
| Entrez Gene |
645
|
| Alt Symbol |
BVRB, FLR, HEL-S-10, SDR43U1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
biliverdin reductase B
|
| Other Description |
BVR-B|FR|GHBP|NADPH-dependent diaphorase|NADPH-flavin reductase|biliverdin reductase B (flavin reductase (NADPH))|biliverdin-IX beta-reductase|epididymis secretory protein Li 10|flavin reductase (NADPH)|green heme-binding protein|short chain dehydrogenase/reductase family 43U, member 1
|
| Swissprots |
P30043 Q32LZ2 P32078 A6NKD8 P53005 B2R5C6
|
| Accessions |
AAP88933 EAW56969 EAW56970 EAW56971 EAW56972 P30043 AK312137 BAG35073 BC109371 AAI09372 BG340491 BU528444 D26308 BAA05370 D32143 BAA06874 EU794593 ACJ13647 NM_000713 NP_000704
|
| Function |
Broad specificity oxidoreductase that catalyzes the NADPH-dependent reduction of a variety of flavins, such as riboflavin, FAD or FMN, biliverdins, methemoglobin and PQQ (pyrroloquinoline quinone). Contributes to heme catabolism and metabolizes linear tetrapyrroles. Can also reduce the complexed Fe(3+) iron to Fe(2+) in the presence of FMN and NADPH. In the liver, converts biliverdin to bilirubin. {ECO:0000269|PubMed:10620517}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:7929092}.
|
| Tissue Specificity |
Predominantly expressed in liver and erythrocytes. At lower levels in heart, lung, adrenal gland and cerebrum. {ECO:0000269|PubMed:7929092}.
|
| Top Pathways |
Riboflavin metabolism, Porphyrin and chlorophyll metabolism
|
![Western Blot: BLVRB Overexpression Lysate (Adult Normal) [NBL1-07994] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for BLVRB.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/10412_BLVRB%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBL1-07994-img0002.jpg)