| Gene Symbol | BLVRB |
|---|---|
| Entrez Gene | 645 |
| Alt Symbol | BVRB, FLR, HEL-S-10, SDR43U1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | biliverdin reductase B |
| Other Description | BVR-B|FR|GHBP|NADPH-dependent diaphorase|NADPH-flavin reductase|biliverdin reductase B (flavin reductase (NADPH))|biliverdin-IX beta-reductase|epididymis secretory protein Li 10|flavin reductase (NADPH)|green heme-binding protein|short chain dehydrogenase/reductase family 43U, member 1 |
| Swissprots | P30043 Q32LZ2 P32078 A6NKD8 P53005 B2R5C6 |
| Accessions | AAP88933 EAW56969 EAW56970 EAW56971 EAW56972 P30043 AK312137 BAG35073 BC109371 AAI09372 BG340491 BU528444 D26308 BAA05370 D32143 BAA06874 EU794593 ACJ13647 NM_000713 NP_000704 |
| Function | Broad specificity oxidoreductase that catalyzes the NADPH-dependent reduction of a variety of flavins, such as riboflavin, FAD or FMN, biliverdins, methemoglobin and PQQ (pyrroloquinoline quinone). Contributes to heme catabolism and metabolizes linear tetrapyrroles. Can also reduce the complexed Fe(3+) iron to Fe(2+) in the presence of FMN and NADPH. In the liver, converts biliverdin to bilirubin. {ECO:0000269|PubMed:10620517}. |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:7929092}. |
| Tissue Specificity | Predominantly expressed in liver and erythrocytes. At lower levels in heart, lung, adrenal gland and cerebrum. {ECO:0000269|PubMed:7929092}. |
| Top Pathways | Riboflavin metabolism, Porphyrin and chlorophyll metabolism |