Gene Symbol | BLVRB |
---|---|
Entrez Gene | 645 |
Alt Symbol | BVRB, FLR, HEL-S-10, SDR43U1 |
Species | Human |
Gene Type | protein-coding |
Description | biliverdin reductase B |
Other Description | BVR-B|FR|GHBP|NADPH-dependent diaphorase|NADPH-flavin reductase|biliverdin reductase B (flavin reductase (NADPH))|biliverdin-IX beta-reductase|epididymis secretory protein Li 10|flavin reductase (NADPH)|green heme-binding protein|short chain dehydrogenase/reductase family 43U, member 1 |
Swissprots | P30043 Q32LZ2 P32078 A6NKD8 P53005 B2R5C6 |
Accessions | AAP88933 EAW56969 EAW56970 EAW56971 EAW56972 P30043 AK312137 BAG35073 BC109371 AAI09372 BG340491 BU528444 D26308 BAA05370 D32143 BAA06874 EU794593 ACJ13647 NM_000713 NP_000704 |
Function | Broad specificity oxidoreductase that catalyzes the NADPH-dependent reduction of a variety of flavins, such as riboflavin, FAD or FMN, biliverdins, methemoglobin and PQQ (pyrroloquinoline quinone). Contributes to heme catabolism and metabolizes linear tetrapyrroles. Can also reduce the complexed Fe(3+) iron to Fe(2+) in the presence of FMN and NADPH. In the liver, converts biliverdin to bilirubin. {ECO:0000269|PubMed:10620517}. |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:7929092}. |
Tissue Specificity | Predominantly expressed in liver and erythrocytes. At lower levels in heart, lung, adrenal gland and cerebrum. {ECO:0000269|PubMed:7929092}. |
Top Pathways | Riboflavin metabolism, Porphyrin and chlorophyll metabolism |
BLVRB CRISPR/Cas9 KO Plasmid (h) - sc-405988 from Santa Cruz Biotechnology
|
||||||||
BLVRB HDR Plasmid (h) - sc-405988-HDR from Santa Cruz Biotechnology
|
||||||||
BLVRB Double Nickase Plasmid (h) - sc-405988-NIC from Santa Cruz Biotechnology
|
||||||||
BLVRB Double Nickase Plasmid (h2) - sc-405988-NIC-2 from Santa Cruz Biotechnology
|
||||||||
BLVRB CRISPR Activation Plasmid (h) - sc-405988-ACT from Santa Cruz Biotechnology
|
||||||||
BLVRB CRISPR Activation Plasmid (h2) - sc-405988-ACT-2 from Santa Cruz Biotechnology
|
||||||||
BLVRB Lentiviral Activation Particles (h) - sc-405988-LAC from Santa Cruz Biotechnology
|
||||||||
BLVRB Lentiviral Activation Particles (h2) - sc-405988-LAC-2 from Santa Cruz Biotechnology
|
||||||||
BLVRB siRNA (h) - sc-62021 from Santa Cruz Biotechnology
|
||||||||
BLVRB shRNA Plasmid (h) - sc-62021-SH from Santa Cruz Biotechnology
|
||||||||
BLVRB shRNA (h) Lentiviral Particles - sc-62021-V from Santa Cruz Biotechnology
|
||||||||
Biliverdin Reductase B/BLVRB RNAi - H00000645-R01 from Novus Biologicals
|
||||||||
MISSION® esiRNA - EHU047791 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN3994 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3994 from Sigma-Aldrich
|
||||||||
BLVRB siRNA (Human) - CRH0441 from Cohesion Biosciences
|
||||||||
BLVRB - MBS8213693 from MyBioSource
|
||||||||
Human BLVRB siRNA - orb260943 from Biorbyt
|
||||||||
BLVRB shRNA Plasmid (Human) - CHH0441 from Cohesion Biosciences
|