| Gene Symbol |
TSSK2
|
| Entrez Gene |
23617
|
| Alt Symbol |
DGS-G, SPOGA2, STK22B, TSK2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
testis-specific serine kinase 2
|
| Other Description |
TSK-2|TSSK-2|diGeorge syndrome protein G|serine/threonine kinase 22B (spermiogenesis associated)|serine/threonine-protein kinase 22B|spermiogenesis associated 2|testis specific serine threonine kinase 2|testis-specific kinase 2|testis-specific serine/threonine-protein kinase 2
|
| Swissprots |
Q8IY55 Q96PF2
|
| Accessions |
BAF41974 CBH30659 EAX03058 Q96PF2 AF362953 AAK98531 BC037781 AAH37781 CR456587 CAG30473 L77564 NM_053006 NP_443732
|
| Function |
Testis-specific serine/threonine-protein kinase required during spermatid development. Phosphorylates TSKS at 'Ser-288' and SPAG16. Involved in the late stages of spermatogenesis, during the reconstruction of the cytoplasm. During spermatogenesis, required for the transformation of a ring-shaped structure around the base of the flagellum originating from the chromatoid body. {ECO:0000269|PubMed:15044604, ECO:0000269|PubMed:18533145, ECO:0000269|PubMed:20729278}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:18495105}. Note=Present in the cytoplasm of elongating spermatids. In spermatozoa, localizes in the equatorial segment, neck, the midpiece and in a specific sperm head compartment (By similarity). In spermatids, concentrates in centrioles during flagellogenesis. {ECO:0000250}.
|
| Tissue Specificity |
Testis-specific. Present in mature spermatozoa (at protein level). {ECO:0000269|PubMed:15044604, ECO:0000269|PubMed:18533145, ECO:0000269|PubMed:20729278}.
|
![Western Blot: TSSK2 Overexpression Lysate (Adult Normal) [NBL1-17394] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for TSSK2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/18542_TSSK2%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBL1-17394-img0002.jpg)