Gene Symbol | TSSK2 |
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Entrez Gene | 23617 |
Alt Symbol | DGS-G, SPOGA2, STK22B, TSK2 |
Species | Human |
Gene Type | protein-coding |
Description | testis-specific serine kinase 2 |
Other Description | TSK-2|TSSK-2|diGeorge syndrome protein G|serine/threonine kinase 22B (spermiogenesis associated)|serine/threonine-protein kinase 22B|spermiogenesis associated 2|testis specific serine threonine kinase 2|testis-specific kinase 2|testis-specific serine/threonine-protein kinase 2 |
Swissprots | Q8IY55 Q96PF2 |
Accessions | BAF41974 CBH30659 EAX03058 Q96PF2 AF362953 AAK98531 BC037781 AAH37781 CR456587 CAG30473 L77564 NM_053006 NP_443732 |
Function | Testis-specific serine/threonine-protein kinase required during spermatid development. Phosphorylates TSKS at 'Ser-288' and SPAG16. Involved in the late stages of spermatogenesis, during the reconstruction of the cytoplasm. During spermatogenesis, required for the transformation of a ring-shaped structure around the base of the flagellum originating from the chromatoid body. {ECO:0000269|PubMed:15044604, ECO:0000269|PubMed:18533145, ECO:0000269|PubMed:20729278}. |
Subcellular Location | Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:18495105}. Note=Present in the cytoplasm of elongating spermatids. In spermatozoa, localizes in the equatorial segment, neck, the midpiece and in a specific sperm head compartment (By similarity). In spermatids, concentrates in centrioles during flagellogenesis. {ECO:0000250}. |
Tissue Specificity | Testis-specific. Present in mature spermatozoa (at protein level). {ECO:0000269|PubMed:15044604, ECO:0000269|PubMed:18533145, ECO:0000269|PubMed:20729278}. |
Active human TSSK2 full length protein - ab70075 from Abcam
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Human TSSK2 full length protein - ab161716 from Abcam
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Human TSSK2 full length protein - ab171601 from Abcam
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Human TSSK2 protein fragment - ab161717 from Abcam
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TSSK2 Antibody Blocking Peptide - LS-E19489 from LifeSpan Bioscience
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TSSK2 Antibody Blocking Peptide - LS-E19490 from LifeSpan Bioscience
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TSSK2 Recombinant Protein - H00023617-P01 from Novus Biologicals
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TSSK2 Partial Recombinant Protein - H00023617-Q01 from Novus Biologicals
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Recombinant Human TSSK2 Protein - NBP2-22856 from Novus Biologicals
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TSSK2 Recombinant Protein - P4789 from Novus Biologicals
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Human TSSK2 Enzyme - orb191436 from Biorbyt
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TSSK2 Blocking Peptide - 33R-8066 from Fitzgerald
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TSSK2 Blocking Peptide - 33R-1983 from Fitzgerald
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TSSK2 protein (His tag) - 80R-2999 from Fitzgerald
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TSSK2 (1-358, His-tag) - AR51117PU-N from Acris Antibodies
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TSSK2 (1-358, His-tag) - AR51117PU-S from Acris Antibodies
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TSSK2 - H00023617-P01-10 from Acris Antibodies
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TSSK2 - H00023617-P01-25 from Acris Antibodies
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TSSK2 - H00023617-Q01-10 from Acris Antibodies
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TSSK2 - H00023617-Q01-25 from Acris Antibodies
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TSSK2 - P4789 from Acris Antibodies
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TSSK2 - P5807 from Acris Antibodies
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TSSK2, 1-358aa, Human, His tag, E.coli - 01-P2293 from ARP American Research Products
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TSSK2 fusion protein - ag4805 from Proteintech Group
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TSSK2 fusion protein - Ag5162 from Proteintech Group
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