TSSK2
| Gene Symbol | TSSK2 |
|---|---|
| Entrez Gene | 23617 |
| Alt Symbol | DGS-G, SPOGA2, STK22B, TSK2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | testis-specific serine kinase 2 |
| Other Description | TSK-2|TSSK-2|diGeorge syndrome protein G|serine/threonine kinase 22B (spermiogenesis associated)|serine/threonine-protein kinase 22B|spermiogenesis associated 2|testis specific serine threonine kinase 2|testis-specific kinase 2|testis-specific serine/threonine-protein kinase 2 |
| Swissprots | Q8IY55 Q96PF2 |
| Accessions | BAF41974 CBH30659 EAX03058 Q96PF2 AF362953 AAK98531 BC037781 AAH37781 CR456587 CAG30473 L77564 NM_053006 NP_443732 |
| Function | Testis-specific serine/threonine-protein kinase required during spermatid development. Phosphorylates TSKS at 'Ser-288' and SPAG16. Involved in the late stages of spermatogenesis, during the reconstruction of the cytoplasm. During spermatogenesis, required for the transformation of a ring-shaped structure around the base of the flagellum originating from the chromatoid body. {ECO:0000269|PubMed:15044604, ECO:0000269|PubMed:18533145, ECO:0000269|PubMed:20729278}. |
| Subcellular Location | Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:18495105}. Note=Present in the cytoplasm of elongating spermatids. In spermatozoa, localizes in the equatorial segment, neck, the midpiece and in a specific sperm head compartment (By similarity). In spermatids, concentrates in centrioles during flagellogenesis. {ECO:0000250}. |
| Tissue Specificity | Testis-specific. Present in mature spermatozoa (at protein level). {ECO:0000269|PubMed:15044604, ECO:0000269|PubMed:18533145, ECO:0000269|PubMed:20729278}. |
TSSK 2 CRISPR/Cas9 KO Plasmid (h) - sc-405216 from Santa Cruz Biotechnology
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TSSK 2 HDR Plasmid (h) - sc-405216-HDR from Santa Cruz Biotechnology
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TSSK 2 Double Nickase Plasmid (h) - sc-405216-NIC from Santa Cruz Biotechnology
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TSSK 2 Double Nickase Plasmid (h2) - sc-405216-NIC-2 from Santa Cruz Biotechnology
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TSSK 2 CRISPR Activation Plasmid (h) - sc-405216-ACT from Santa Cruz Biotechnology
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TSSK 2 CRISPR Activation Plasmid (h2) - sc-405216-ACT-2 from Santa Cruz Biotechnology
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TSSK 2 Lentiviral Activation Particles (h) - sc-405216-LAC from Santa Cruz Biotechnology
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TSSK 2 Lentiviral Activation Particles (h2) - sc-405216-LAC-2 from Santa Cruz Biotechnology
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TSSK 2 siRNA (h) - sc-76768 from Santa Cruz Biotechnology
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TSSK 2 shRNA Plasmid (h) - sc-76768-SH from Santa Cruz Biotechnology
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TSSK 2 shRNA (h) Lentiviral Particles - sc-76768-V from Santa Cruz Biotechnology
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TSSK2 RNAi - H00023617-R02 from Novus Biologicals
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MISSION® esiRNA - EHU225391 from Sigma-Aldrich
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MISSION® esiRNA - EHU001101 from Sigma-Aldrich
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MISSION® siRNA - SIHK2360 from Sigma-Aldrich
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MISSION® siRNA - SIHK2362 from Sigma-Aldrich
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MISSION® siRNA - SIHK2361 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN22140 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22140 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR00136 from Sigma-Aldrich
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TSSK2 siRNA (Human) - CRH8399 from Cohesion Biosciences
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TSSK2 - MBS8216616 from MyBioSource
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shRNA set against Human TSSK2 (NM_053006.4) - SHH436620 from Creative biogene
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Human TSSK2 siRNA - orb268901 from Biorbyt
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TSSK2 shRNA Plasmid (Human) - CHH8399 from Cohesion Biosciences
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