IRS4

Gene Symbol	IRS4
Entrez Gene	8471
Alt Symbol	IRS-4, PY160
Species	Human
Gene Type	protein-coding
Description	insulin receptor substrate 4
Other Description	160 kDa phosphotyrosine protein|phosphoprotein of 160 kDa|pp160
Swissprots	O14654
Accessions	EAX02682 O14654 AF007567 AAC51738 AL832136 BC156188 AAI56189 BC156977 AAI56978 HG512649 XM_005262220 XP_005262277 XM_006724713 XP_006724776 XM_011531061 XP_011529363 NM_003604 NP_003595
Function	Acts as an interface between multiple growth factor receptors possessing tyrosine kinase activity, such as insulin receptor, IGF1R and FGFR1, and a complex network of intracellular signaling molecules containing SH2 domains. Involved in the IGF1R mitogenic signaling pathway. Promotes the AKT1 signaling pathway and BAD phosphorylation during insulin stimulation without activation of RPS6KB1 or the inhibition of apoptosis. Interaction with GRB2 enhances insulin-stimulated mitogen-activated protein kinase activity. May be involved in nonreceptor tyrosine kinase signaling in myoblasts. Plays a pivotal role in the proliferation/differentiation of hepatoblastoma cell through EPHB2 activation upon IGF1 stimulation. May play a role in the signal transduction in response to insulin and to a lesser extent in response to IL4 and GH on mitogenesis. Plays a role in growth, reproduction and glucose homeostasis. May act as negative regulators of the IGF1 signaling pathway by suppressing the function
Subcellular Location	Cell membrane {ECO:0000269|PubMed:9553137}; Peripheral membrane protein {ECO:0000269|PubMed:9553137}; Cytoplasmic side {ECO:0000269|PubMed:9553137}.
Tissue Specificity	Expressed in myoblasts. Expressed in liver and hepatocellular carcinoma. {ECO:0000269|PubMed:12639902, ECO:0000269|PubMed:17408801}.
Top Pathways	Insulin signaling pathway, Adipocytokine signaling pathway, Type II diabetes mellitus, cGMP-PKG signaling pathway, AMPK signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• Cell/Tissue/Blood Products

Insulin receptor substrate 4, IRS4, Human, ELISA Kit - E0288h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t

insulin receptor substrate 4, ELISA Kit - MBS9337132 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Insulin receptor substrate 4, IRS-4, ELISA Kit - MBS9305549 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Insulin receptor substrate 4, IRS-4, ELISA Kit - MBS9305577 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Human IRS4 ELISA Kit (Custom ELISA) - LS-F14209 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 246.9-20000 pg/ml

Mouse IRS4 ELISA Kit (Custom ELISA) - LS-F14208 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 246.9-20000 pg/ml

Human IRS4 ELISA Kit - E019991 from Biobool Category ELISA Kit

Human IRS-4 ELISA Kit - E019993 from Biobool Category ELISA Kit

IRS4 ELISA Kit (Human) (OKEH05880) - OKEH05880 from Aviva Systems Biology Category ELISA Kit Prices $440.00 Sizes 96 wells Sensitivity 0.078 ng/mL Range 0.156-10 ng/mL

Insulin receptor substrate 4, ELISA Kit - MBS289376 from MyBioSource Category ELISA Kit Prices $380.00, $500.00, $2,170.00, $3,840.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Pig IRS4 ELISA Kit (Competitive EIA) - LS-F38876 from LifeSpan Bioscience Category ELISA Kit Sensitivity 91.4 Range 246.9-20000 pg/ml

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