| Gene Symbol |
IRS4
|
| Entrez Gene |
8471
|
| Alt Symbol |
IRS-4, PY160
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
insulin receptor substrate 4
|
| Other Description |
160 kDa phosphotyrosine protein|phosphoprotein of 160 kDa|pp160
|
| Swissprots |
O14654
|
| Accessions |
EAX02682 O14654 AF007567 AAC51738 AL832136 BC156188 AAI56189 BC156977 AAI56978 HG512649 XM_005262220 XP_005262277 XM_006724713 XP_006724776 XM_011531061 XP_011529363 NM_003604 NP_003595
|
| Function |
Acts as an interface between multiple growth factor receptors possessing tyrosine kinase activity, such as insulin receptor, IGF1R and FGFR1, and a complex network of intracellular signaling molecules containing SH2 domains. Involved in the IGF1R mitogenic signaling pathway. Promotes the AKT1 signaling pathway and BAD phosphorylation during insulin stimulation without activation of RPS6KB1 or the inhibition of apoptosis. Interaction with GRB2 enhances insulin-stimulated mitogen-activated protein kinase activity. May be involved in nonreceptor tyrosine kinase signaling in myoblasts. Plays a pivotal role in the proliferation/differentiation of hepatoblastoma cell through EPHB2 activation upon IGF1 stimulation. May play a role in the signal transduction in response to insulin and to a lesser extent in response to IL4 and GH on mitogenesis. Plays a role in growth, reproduction and glucose homeostasis. May act as negative regulators of the IGF1 signaling pathway by suppressing the function
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:9553137}; Peripheral membrane protein {ECO:0000269|PubMed:9553137}; Cytoplasmic side {ECO:0000269|PubMed:9553137}.
|
| Tissue Specificity |
Expressed in myoblasts. Expressed in liver and hepatocellular carcinoma. {ECO:0000269|PubMed:12639902, ECO:0000269|PubMed:17408801}.
|
| Top Pathways |
Insulin signaling pathway, Adipocytokine signaling pathway, Type II diabetes mellitus, cGMP-PKG signaling pathway, AMPK signaling pathway
|
![Western Blot: IRS4 Overexpression Lysate (Adult Normal) [NBL1-12040] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for IRS4.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/7492_IRS4%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-12040-img0002.jpg)