IRS4

Gene Symbol	IRS4
Entrez Gene	8471
Alt Symbol	IRS-4, PY160
Species	Human
Gene Type	protein-coding
Description	insulin receptor substrate 4
Other Description	160 kDa phosphotyrosine protein|phosphoprotein of 160 kDa|pp160
Swissprots	O14654
Accessions	EAX02682 O14654 AF007567 AAC51738 AL832136 BC156188 AAI56189 BC156977 AAI56978 HG512649 XM_005262220 XP_005262277 XM_006724713 XP_006724776 XM_011531061 XP_011529363 NM_003604 NP_003595
Function	Acts as an interface between multiple growth factor receptors possessing tyrosine kinase activity, such as insulin receptor, IGF1R and FGFR1, and a complex network of intracellular signaling molecules containing SH2 domains. Involved in the IGF1R mitogenic signaling pathway. Promotes the AKT1 signaling pathway and BAD phosphorylation during insulin stimulation without activation of RPS6KB1 or the inhibition of apoptosis. Interaction with GRB2 enhances insulin-stimulated mitogen-activated protein kinase activity. May be involved in nonreceptor tyrosine kinase signaling in myoblasts. Plays a pivotal role in the proliferation/differentiation of hepatoblastoma cell through EPHB2 activation upon IGF1 stimulation. May play a role in the signal transduction in response to insulin and to a lesser extent in response to IL4 and GH on mitogenesis. Plays a role in growth, reproduction and glucose homeostasis. May act as negative regulators of the IGF1 signaling pathway by suppressing the function
Subcellular Location	Cell membrane {ECO:0000269|PubMed:9553137}; Peripheral membrane protein {ECO:0000269|PubMed:9553137}; Cytoplasmic side {ECO:0000269|PubMed:9553137}.
Tissue Specificity	Expressed in myoblasts. Expressed in liver and hepatocellular carcinoma. {ECO:0000269|PubMed:12639902, ECO:0000269|PubMed:17408801}.
Top Pathways	Insulin signaling pathway, Adipocytokine signaling pathway, Type II diabetes mellitus, cGMP-PKG signaling pathway, AMPK signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• Cell/Tissue/Blood Products

Human IRS4 protein fragment - ab160045 from Abcam Category Protein Source Wheat germ Species Human

IRS4 Antibody Blocking Peptide - LS-E27999 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human IRS4 Protein - H00008471-Q01 from Novus Biologicals Category Protein Prices $250.00 Sizes 2 µg Source Wheat Germ Species Human

IRS4-Antibody-C-term-Blocking-peptide - BP12330b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

IRS4 - H00008471-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

IRS4 - H00008471-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

IRS4 fusion protein - ag16300 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

IRS4 fusion protein - ag17485 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

Recombinant Human Insulin receptor substrate 4(IRS4) ,partial - CSB-YP011832HU CSB-EP011832HU CSB-BP011832HU CSB-MP011832HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

IRS4 Protein - NBP2-14130PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

IRS4 Peptide, Human - M34GP07752H from Creative Peptides Category Peptide Source Synthetic. Species Human

Recombinant Insulin Receptor Substrate 4 (IRS4) - RPU53634 from Biomatik Category Protein Prices $198.00, $387.00, $619.00, $738.00 Sizes 10 µg, 50 µg, 100 µg, 200 µg Source E.coli Species Human

IRS4 Recombinant Protein (OPCD00203) - OPCD00203 from Aviva Systems Biology Category Protein Source E.coli Species Human

Insulin Receptor Substrate 4, Recombinant Protein - MBS2034187 from MyBioSource Category Protein Prices $195.00, $420.00, $650.00 Sizes 10 µg, 50 µg, 100 µg Source E Coli Species Mouse

Insulin Receptor Substrate 4, Recombinant Protein - MBS2034161 from MyBioSource Category Protein Prices $190.00, $405.00, $625.00 Sizes 10 µg, 50 µg, 100 µg Source E Coli Species Human

Insulin receptor substrate 4 (IRS4), partial, Recombinant Protein - MBS1176316 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

Irs4 Immunizing peptide - orb66472 from Biorbyt Category Peptide

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